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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Water-Soluble Glutamic Acid Derivatives Produced in Culture by Penicillium solitum IS1-A from King George Island, Maritime Antarctica

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Author(s):
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Rodriguez, Julie P. G. [1] ; Bernardi, Darlon I. [1] ; Gubiani, Juliana R. [1] ; de Oliveira, Juliana Magalhaes [2] ; Morais-Urano, Raquel P. [1] ; Bertonha, Ariane F. [1] ; Bandeira, Karin F. [1] ; Bulla, Jairo I. Q. [1] ; Sette, Lara D. [3] ; Ferreira, Antonio G. [2] ; Batista, Jr., Joao M. [4] ; Silva, Thayna de Souza [5] ; dos Santos, Raquel Alves [5] ; Martins, Carlos H. G. [5] ; Lira, Simone P. [6] ; da Cunha, Marcos G. [7] ; Trivella, Daniela B. B. [7] ; Grazzia, Nathalia [8] ; Gomes, Natalia E. S. [8] ; Gadelha, Fernanda [8] ; Miguel, Danilo C. [8] ; Cauz, Ana Carolina G. [8] ; Brocchi, Marcelo [8] ; Berlinck, Roberto G. S. [1]
Total Authors: 24
Affiliation:
[1] Univ Sao Paulo, Inst Quim Sao Carlos, CP 780, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
[3] Univ Estadual Paulista, Inst Biociencias, Dept Bioquim & Microbiol, Campus Rio Claro, Avenida 24-A, 1515, Rio Claro, SP - Brazil
[4] Univ Fed Sao Paulo, Inst Ciencia & Tecnol, BR-12231280 Sao Jose Dos Campos, SP - Brazil
[5] Univ Franca, Nucleo Pesquisa Ciencia & Tecnol, Ave Dr Armando Salles Oliveira, 201 Pq Univ, BR-14404600 Franca, SP - Brazil
[6] Univ Sao Paulo, Dept Ciencias Exatas, Escola Super Agr Luiz de Queiroz, Agron, Ave Padua Dias 11, CP 9, BR-13418900 Piracicaba, SP - Brazil
[7] Natl Ctr Res Energy & Mat, Brazilian Biosci Natl Lab, Giuseppe Maximo Scolfaro 10000, BR-13083970 Campinas, SP - Brazil
[8] Univ Estadual Campinas, Inst Biol, BR-13083862 Campinas, SP - Brazil
Total Affiliations: 8
Document type: Journal article
Source: Journal of Natural Products; v. 83, n. 1, p. 55-65, JAN 2020.
Web of Science Citations: 0
Abstract

A new method of screening was developed to generate 770 organic and water-soluble fractions from extracts of nine species of marine sponges, from the growth media of 18 species of marine-derived fungi, and from the growth media of 13 species of endophytic fungi. The screening results indicated that water-soluble fractions displayed significant bioactivity in cytotoxic, antibiotic, anti-Leishmania, anti-Trypanosoma cruzi, and inhibition of proteasome assays. Purification of water-soluble fractions from the growth medium of Penicillium solitum IS1-A provided the new glutamic acid derivatives solitumine A (1), solitumine B (2), and solitumidines A-D (3-6). The structures of compounds 1-6 have been established by analysis of spectroscopic data, chemical derivatizations, and vibrational circular dichroism calculations. Although no biological activity could be observed for compounds 1-6, the new structures reported for 1-6 indicate that the investigation of water-soluble natural products represents a relevant strategy in finding new secondary metabolites. (AU)

FAPESP's process: 13/50228-8 - Biodiversity components, and its metabolic characters, of Brazilian Islands
Grantee:Roberto Gomes de Souza Berlinck
Support type: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 16/16033-3 - Bromopyrrole alkaloids from the cultured microbiome of the marine sponge Tedania brasiliensis
Grantee:Jairo Iván Quintana Bulla
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 16/21341-9 - Hydrophilic and bioactive secondary metabolites produced by filamentous fungi
Grantee:Darlon Irineu Bernardi
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 13/23153-7 - Use of dereplication for the discovery of new bioactive natural products from marine and endophytic microorganisms
Grantee:Raquel Peres de Morais Urano
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/06014-4 - New secondary metabolites of endophytic and marine organisms as proteasome inhibitors: a validated target against cancer
Grantee:Juliana Regina Gubiani
Support type: Scholarships in Brazil - Post-Doctorate