|Support type:||Scholarships in Brazil - Scientific Initiation|
|Effective date (Start):||September 01, 2011|
|Effective date (End):||June 30, 2012|
|Field of knowledge:||Health Sciences - Pharmacy - Toxicological Analysis|
|Principal Investigator:||Ana Paula de Melo Loureiro|
|Grantee:||Antonio Anáx Falcão de Oliveira|
|Home Institution:||Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil|
The exposure to air pollution constituents can damage biomolecules, leading to diseases such as cancer. Fine particles with aerodynamic diameter less than 2.5 micrometre (MP2,5) draw attention because they can penetrate the respiratory tract and be deposited in the terminal portion of the bronchi and alveoli, causing cell damage. Such particles have variable composition and may act as carriers of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene, metaland water soluble ions . Given the capacity of its constituents to cause damage to the DNA, it is evident the probable relationship of the particulate matter with the appearance of pathologies linked to the respiratory tract and probably other body tissues. This justifies the importance of further studies in order to deepen the knowledge about the health risks caused by this type of pollutant, primarily in other organs such as liver and kidney that are directly linked to the metabolism and excretion of xenobiotics. Therefore, this project proposes the evaluation of global DNA methylation and DNA damage caused by oxidative stress and inflammation in lung, liver and kidney of Swiss and A/J mice chronically exposed to particulate matter concentrated from the air of the city of Sao Paulo, Cerqueira Cesar region in the Faculty of Medicine, University of São Paulo.