Influence of inflammatory response in the malignancy grade of canine squamous cell carcinoma

• Grant number: 11/14232-5
• Support type: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): November 01, 2011
• Effective date (End): October 31, 2012
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Pathology
• Principal researcher: Rosemeri de Oliveira Vasconcelos
• Grantee: Clarissa Helena Santana
• Home Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil

Abstract

Currently, research on tumors in dogs are directed to the immunological aspects, prognostic markers,diagnosis and treatment, especially in mammary tumors in dogs as it is similar to breast tumors in women and serve as an experimental model for studies in women. In the other skin tumors of dogs, among them, squamous cell carcinoma, studies that focus on the inflammatory response of the dog in the face of these tumors are very rare. Just as certain pathogens, tumor cells are able to modulate the host immune system to favor their growth and survival. Inflammatory cells in these cases can act against the host by producing growth factors, cytokines or enzymes that are beneficial to the tumor, favoring neovascularization, extracellular matrix degradation and invasion of blood vessels to reach other organs. Therefore, it becomes crucial to the development of research that addresses these issues in order to elucidate the complex pathogenesis of these tumors and contribute to future studies of tumor immunotherapy. Therefore, the aim of this study was to assess the predominant profile of leukocytes (lymphocytes, macrophages and plasma cells) infiltrate in canine squamous cell carcinoma and compare these findings with histologic type less (non keratinized) or more differentiated (keratinizing) of this tumor.