Searching for new antigens for canine visceral leishmaniasis serodiagnostic: study of Lc06 protein.

• Grant number: 11/15508-4
• Support type: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): September 01, 2011
• Effective date (End): January 31, 2014
• Field of knowledge: Biological Sciences - Parasitology - Protozoology of Parasites
• Principal researcher: Marcia Aparecida Silva Graminha
• Grantee: Mayara Lúcia Del Cistia
• Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Associated scholarship(s): 13/11508-5 - Proteomic analysis of Leishmania mexicana by permeabilization of different cell membranes with digitonin, BE.EP.IC

Abstract

Visceral leishmaniasis (VL) is the most severe clinical form of leishmaniasis and can fatal if not treated. Infected dogs are potential reservoirs of the illness and a specific diagnosis is required for the identification of the infected animals in order to promote better epidemiology control. The development of a more sensible and specific diagnostic test is important for detention of potential reservoirs, especially in Brazil where the infected animals are euthanized. In literature, many works disagree about the specificity of the tests currently used. This work has as objective to report the isolation and test of a Leishmania infantun (syn = chagasi) specific gene called Lc 06, which expression product, the protein rLc 06, could be a potential epitope for the development of a new diagnostic method.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NOGUEIRA, CAMILA TITA; DEL CISTIA, MAYARA LUCIA; URBACZEK, ANA CAROLINA; JUSI, MARCIA M. G.; ARENAS VELASQUEZ, ANGELA MARIA; MACHADO, ROSANGELA ZACARIAS; FERREIRA, HENRIQUE; HENRIQUE-SILVA, FLAVIO; LANGONI, HELIO; DA COSTA, PAULO INACIO; et al. Potential application of rLc36 protein for diagnosis of canine visceral leishmaniasis. Memórias do Instituto Oswaldo Cruz, v. 113, n. 3, p. 197-201, MAR 2018. (11/06995-9, 11/15508-4)