Metal complexes with rimantadine: synthesis, spectroscopic characterization and citotoxic studies.

• Grant number: 11/14812-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2011
• End date: September 30, 2012
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Pedro Paulo Corbi
• Grantee: Débora Dezotti Camargo
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

This work deals with the synthesis, spectroscopic characterization and biological assays of metal complexes with rimantadine. The ligand is used as an antiviral agents against Influenza A virus. The complexes will be synthesized under aqueous and/or ethanolic solutions, characterized by a set of chemical and spectroscopic analysis, with emphasis on 1H, 13C and 15 NMR spectroscopic measurements, and evaluated as potential antiviral and antitumor agents.