Evaluation of serum acute phase proteins in cats with lymphoma and its relation with survival.

• Grant number: 11/15599-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2011
• End date: October 31, 2012
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Sílvia Regina Ricci Lucas
• Grantee: Ana Luiza Nairismagi Alves
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Evaluation of serum acute phase proteins in cats with lymphoma and its relation with survival.Researcher: Sílvia Regina Ricci Lucas, DVM, MSc, PhDInstitution: University of São PauloAbstractLymphoma belongs to a group of malignancies that have in common their origin in lymphoreticular cells, and is generally manifested in lymphoid tissues. In the evolution of lymphoma, there is a generalized reaction of the body in a non-specific and acute injury against local and / or systemic diseases that compromise the homeostasis, known as acute phase response, which leads to a significant change in protein synthesis by the liver, resulting in an increase of some proteins known as acute phase proteins. Therefore, taking into account the importance of lymphomas in routine clinical care of cats, the measurement of serum acute phase proteins, notably alpha-1 acid glycoprotein and serum amyloid A in cats, can be very useful for monitoring chemotherapy in cats with lymphoma as it can be an increase in their serum at the time of diagnosis, decreased during treatment indicates regression of the disease. Thus, the objectives of this study are to evaluate serum levels of acute phase proteins serum amyloid A and a1-acid glycoprotein in cats with lymphoma at diagnosis and to verify if there is a correlation with survival time.