Enzyme immobilization on superparamagnetic nanoparticles

• Grant number: 11/18391-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2011
• End date: May 31, 2014
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Henrique Eisi Toma
• Grantee: Marcos Felipe Calegari Andrade
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 09/08584-6 - Supramolecular chemistry and nanotechnology, AP.TEM

Abstract

Enzymes modified or immobilized using magnetic nanoparticles are being investigated from the point of view of methodology improvement, exploring several coupling alternatives, as well as, from the mechanistic point of view, by constructing model, biomimetic systems. One of the major targets is the exploration of the enzyme recyclability, in special, the CAL B lipase, and of the applications in trans-esterification of secondary alcohols and their enantiomeric resolution.(AU)