Research potassium channel voltage-dependent induction and maintenance of persistent and neuropathic hypernociception.

• Grant number: 11/11931-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: January 01, 2012
• End date: December 31, 2012
• Field of knowledge: Biological Sciences - Pharmacology - General Pharmacology
• Principal Investigator: Sérgio Henrique Ferreira
• Grantee: Jozi Godoy Figueiredo
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Pain is considered a major social problem due to the difficulty of its controltherapeutic. The chronic pain of inflammatory origin are determined by injuryperipheral tissue and persistent activation of nociceptors, resulting in plasticityfunctional nervous system, changes in nociceptive sensitivity and expressionreceptors, ion channels, neurotransmitters and enzymes. In order to studypathophysiological components of chronic pain of inflammatory origin, our groupdeveloped an experimental protocol consisting of daily administration oftype prostaglandin E2 (14 days) in the paw of rats induces a state ofpersistent hypernociception. Work reported in the literature have shown thathipernociceptivos mediating agents can influence the sensitivity of neuronalcause the closing of K channels in voltage-dependent peripheral neuronsshowing that these channels are also important during hypernociception.In this project we propose to evaluate the mechanisms of intracellular signalingchannel voltage-dependent potassium that may be involved in the induction andmaintenance of persistent hypernociception and also neuropathic. To this end,evaluate changes in the expression of potassium ion channels voltagemdependentesin dorsal root ganglion during induction and maintenance ofpersistent and neuropathic hypernociception using models already reported inliterature (persistent pain: management models and prostaglandin Adjuvantcomplete Freund's neuropathic pain through the nerve ligation model). thisapproaches will be used as molecular biology and electrophysiology to evaluateexpression and possible involvement of these channels in the induction or maintenance ofpersistent and neuropathic mechanical hypernociception.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FIGUEIREDO, JOZI; FERREIRA, ANA ELISA; SILVA, RANGEL LEAL; ULLOA, LUIS; GRIECO, PAOLO; CUNHA, THIAGO MATTAR; FERREIRA, SERGIO HENRIQUE; CUNHA, FERNANDO DE QUEIROZ; KANASHIRO, ALEXANDRE. NDP-MSH inhibits neutrophil migration through nicotinic and adrenergic receptors in experimental peritonitis. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, v. 386, n. 4, p. 311-318, APR 2013. (12/04237-2, 11/11931-0, 11/20343-4)