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Impact of regular moderate physical activity in delaying immunosenescence in elderly people

Grant number: 11/18268-4
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2012
Effective date (End): October 31, 2014
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Gil Benard
Grantee:Léia Cristina Rodrigues da Silva
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The increase in life expectancy of the populations has fostered the interest in the understanding of the ageing process. This process, called immunosenescence, is associated with an immunedysregulation, notably of the Th-1/Th-2 balance, with progressive predominance of Th-2 responses. Decreased IFN-g secretion and increased IL-4 and IL-10 secretion are seen in lymphocytes from aged as compared with young adults. The production of IL-1, IL-6, IL-8 e TNF- is also increased, contrasting with the decreased production of IFN-g and IL-2. The reduced efficacy of vaccination and the increased rate of infections in this population are likely due to the decreased number of naïve T cells. In the elderly, the accumulation of T CD8+CD28- cells (the loss of CD28 expression being a marker of replicative senescence) is also associated with the lack of control of infections. The detrimental impact of ageing and immunosenescence led to the development of protocols aiming at reducing this impact. One of such protocols is the regular practice of exercises. This study aims to verify whether aged people undergoing regular moderate physical activity (participation in training for competition of up to 10.000 meters) have improvement in immunological parameters and, genotypically, with slowing of the shortening of telomere length. For this, 40 healthy aged athletes (>65 years) will be studied in comparison with 40 healthy aged (>65 years) sedentary individuals. Telomere length of several subpopulations (TCD8+CD28+ and TCD8+CD28- cells, naïve and memory TCD4+ cells) will be studied by the Flow-FISH method. In parallel, the proliferative and cytokine responses (IL-2, IL-10, TNF-± e INF-g) and markers of apoptosis of these cells will be evaluated.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RODRIGUES SILVA, LEIA CRISTINA; DE ARAUJO, ADRIANA LADEIRA; FERNANDES, JULIANA RUIZ; TOLEDO MATIAS, MANUELLA DE SOUSA; SILVA, PAULO ROBERTO; DUARTE, ALBERTO J. S.; GARCEZ LEME, LUIZ EUGENIO; BENARD, GIL. Moderate and intense exercise lifestyles attenuate the effects of aging on telomere length and the survival and composition of T cell subpopulations. AGE, v. 38, n. 1 FEB 2016. Web of Science Citations: 22.
DE ARAUJO, ADRIANA LADEIRA; RODRIGUES SILVA, LEIA CRISTINA; FERNANDES, JULIANA RUIZ; TOLEDO MATIAS, MANUELLA DE SOUSA; BOAS, LUCY SANTOS; MACHADO, CLARISSE MARTINS; GARCEZ-LEME, LUIZ EUGENIO; BENARD, GIL. Elderly men with moderate and intense training lifestyle present sustained higher antibody responses to influenza vaccine. AGE, v. 37, n. 6 DEC 2015. Web of Science Citations: 10.

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