Biotransformation of kaurenoic acid by filamentous fungi and evaluation of the anti-phytopathogenic properties of the obtained metabolites.

• Grant number: 11/21638-8
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: March 01, 2012
• End date: February 29, 2016
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Sergio Ricardo Ambrosio
• Grantee: Thiago Sousa Porto
• Host Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil
• Associated research grant: 07/54762-8 - Obtaining structural analogues of pimaradienoic acid through the process of fungal biotransformation and study of the effect of these metabolites on the activity of the TcDHODH enzyme and on the contraction of the vascular smooth muscle of the aorta artery of mice, AP.BTA.JP

Abstract

The goal of the present project is obtain derivatives from kaurenoic acid (KA), a diterpene found in high amounts in the leaves of Mikania glomerata, which is associated with several biological activities, including its antifungal properties. The structural modifications in the chemical skeleton of KA will be performed by biotransformation processes using two different microorganisms, Aspergillus phoenix and Phomopsis longicolla. The obtained metabolites will be evaluated against a panel of phytopathogens responsible for serious agricultural diseases.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

OLIVEIRA, LARISSA COSTA; PORTO, THIAGO SOUZA; COLMANETTE JUNIOR, ARTHUR HENRIQUE; CONCEICAO SANTOS, MARIO FERREIRA; RAMOS, HENRIQUE PEREIRA; BRAUN, GLAUCIA HOLLAENDER; DE LIMA PAULA, LUCAS ANTONIO; BASTOS, JAIRO KENUPP; JACOMETTI CARDOSO FURTADO, NIEGE ARACARI; TAME PARREIRA, RENATO LUIS; et al. Schistosomicidal activity of kaurane, labdane and clerodane-type diterpenes obtained by fungal transformation. Process Biochemistry, v. 98, p. 34-40, NOV 2020. (11/13630-7, 11/21638-8, 17/02592-3)