|Support type:||Scholarships in Brazil - Doctorate|
|Effective date (Start):||April 01, 2012|
|Effective date (End):||March 31, 2016|
|Field of knowledge:||Physical Sciences and Mathematics - Chemistry - Organic Chemistry|
|Principal Investigator:||Niege Araçari Jacometti Cardoso Furtado|
|Grantee:||Tatiane Cruz de Carvalho|
|Home Institution:||Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil|
It has been described that drugs biotransformation carried out by filamentous fungi can furnish the same metabolite produced in human metabolism and more than 30 drugs in the market are modified by gastrointestinal bactéria. The purpose of this project is to carry out biotransformation processes of b-caryophyllene and acid 3-acetoxy-copalic using filamentous fungi and gastrointestinal bacteria. Promising processes will be selected for preparative scale and the majority compounds will be isolated, their chemical structures will be elucidated and their cytotoxic potential will be evaluated. b-caryophyllene and acid 3-acetoxy-copalic belong to sesquiterpenes and diterpenes classes, respectively, which are studied due to their detected biological activities. b-caryophyllene is a sesquiterpene which can be found as majority compound in essential oil from several genus of plants from different regions and many biological activities were reported for this sesquiterpene, such as anti-swelling, phago-repellent, anti-inflammatory, antitumor, bactericidal and others. The acid 3-acetoxy-copalic is a diterpene belonging to the skeleton type labdan. Diterpenes are compounds which are studied due to their presence in many plant species and also due to their biological potential, among them antimicrobial, anti-inflammatory, trypanocidal, antitumor, among others. This study may contribute to the understanding of b-caryophyllene and acid 3-acetoxy-copalic in vivo metabolism and it will provide information about the cytotoxicity of the produced metabolites.