Study of the immunomodulatory activities of Tithonia diversifolia in human neutrophils.

• Grant number: 11/18174-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: January 01, 2012
• End date: December 31, 2012
• Field of knowledge: Biological Sciences - Immunology - Applied Immunology
• Principal Investigator: Ana Paula Campanelli
• Grantee: Aneli Eiko Abe
• Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil

Abstract

The immunomodulatory activity of several medicinal plants from the family Asteraceae is due to the presence of sesquiterpene lactones. The immunomodulatory activity of the Tithonia diversifolia in human neutrophils will be investigated. Methods and Results: Neutrophils will be cultured with fMLP or budlein A for 18h and cytokines production analyzed by ELISA.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ABE, ANELI E.; DE OLIVEIRA, CARINE E.; DALBONI, THALITA M.; CHAGAS-PAULA, DANIELA A.; ROCHA, BRUNO A.; DE OLIVEIRA, REJANE B.; GASPAROTO, THAIS H.; DA COSTA, FERNANDO B.; CAMPANELLI, ANA P.. Anti-inflammatory sesquiterpene lactones from Tithonia diversifolia trigger different effects on human neutrophils. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 25, n. 2, p. 111-116, MAR-APR 2015. (08/02185-0, 11/01862-0, 11/18174-0, 09/14127-7, 10/10940-2, 10/19317-6)