Evaluation of tannic acid (tannin) on experimental pythiosis in rabbits.

• Grant number: 11/14710-4
• Support Opportunities: Scholarships in Brazil - Master
• Start date until: March 01, 2012
• End date until: February 28, 2014
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Preventive Veterinary Medicine
• Principal Investigator: Sandra de Moraes Gimenes Bosco
• Grantee: Rodrigo Trolezi
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Pythiosis, whose etiological agent is the oomycete Pythium insidiosum, is an emergent disease that occurs with great frequency in tropical and subtropical countries and affects several animal species, including human, being more prevalent in equines.The disease is characterized by granulomatous and itchy lesions mainly in cutaneous/subcutaneous tissues, and may also present as vascular, ocular and sistemic disease, compromising several organs and tissues.In Brazil, animal pythiosis was reported in several species, mainly in equines in Pantanal regions of Mato Grosso state. The first human case was recently reported and illustrates the difficulty to establish the correct diagnosis, since this pathogen is frequently misdiagnosed as zygomycetes fungi. Treatment of pythiosis is difficult, since the pathogen does not respond well to antifungal drugs available, requiring some extensive surgical procedures, when it is possible. Immunotherapy or Anfotericin B, in association to surgical debridment, has shown some satisfactory results, although relapses occur frequently. Medicinal plants have shown several applications in the past and are still being studying nowadays for therapeutic purposes. Due to the promising results obtained with leafs and bark extracts of "barbatimão" and, mainly with purified tannic acid (tannin), on the in vitro growth of P. insidiosum (Scientific Iniciation, grant number 09/18466-0), it is necessary the in vivo evaluation of tannin as a possible alternative treatment for pythiosis.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TROLEZI, RODRIGO; AZANHA, JULIANA MAZIERO; PASCHOAL, NATLIA RODRIGUES; CHECHI, JESSICA LUANA; DIAS SILVA, MARCELO JOSE; FABRIS, VICIANY ERIC; VILEGAS, WAGNER; KANENO, RAMON; FERNANDES JUNIOR, ARY; GIMENES BOSCO, SANDRA DE MORAES. Stryphnodendron adstringens and purified tannin on Pythium insidiosum: in vitro and in vivo studies. ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS, v. 16, FEB 23 2017. (09/18466-0, 11/14710-4, 11/21834-1)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

TROLEZI, Rodrigo. Efeito da anfotericina B, extrato da casca de bartimão, ácido tânico purificado, DMSO e corticosteróide na tratamento da pitiose experimental em coelhos. 2014. Master's Dissertation - Universidade Estadual Paulista (Unesp). Instituto de Biociências. Botucatu Botucatu.