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Effects of the solid dispersion of curcumin in endocrine and metabolic alterations in experimental sepsis

Grant number: 11/14711-0
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): March 31, 2013
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal researcher:Maria José Alves da Rocha
Grantee:Letycia Silvano da Silva
Home Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


In our laboratory, using the experimental model of sepsis by cecal ligation and puncture (CLP), we found that in the initial phase of sepsis occurs an increase in secretion of vasopressin, which does not happen in the late phase, mainly when the organism would need more of the hormone at this stage occurs a progressive hypotension that can lead to septic shock and death.New clinical and experimental researches have been conducted to evaluate conventional and innovative therapies to treat sepsis. In the search for new treatments we will use a solid dispersion of curcumin (DS17), which has a great anti-inflammatory activity, to check their effects on metabolic and endocrine changes during experimental sepsis.For this purpose, male Wistar rats, weighing 250-300g will be treated for a period of seven days with DS17 dissolved in water and administered by gavage, and then they will be subjected to sepsis by CLP. On the day of the experiment, the animals will be separated into two groups, one group CLP and another group fictitious operation (OF). Then the animals will be beheaded in the times of 4, 6 and 24 hours and will have blood collected. Plasma and serum will be separated for determination of blood glucose, serum sodium, nitric oxide, vasopressin, insulin, IL-1, IL-6, TNF-alfa and heat shock protein. Another group of animals will have the survival evaluated by two days. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVA, LETYCIA SILVANO; ROCHA CATALAO, CARLOS HENRIQUE; FELIPPOTTI, TATIANA TOCCHINI; DE OLIVEIRA-PELEGRIN, GABRIELA RAVANELLI; PETENUSCI, SERGIO; PEDRO DE FREITAS, LUIS ALEXANDRE; ALVES ROCHA, MARIA JOSE. Curcumin suppresses inflammatory cytokines and heat shock protein 70 release and improves metabolic parameters during experimental sepsis. Pharmaceutical Biology, v. 55, n. 1, p. 269-276, 2017. Web of Science Citations: 10.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SILVA, Letycia Silvano da. in vivo effects of solid dispersion of curcumin in metabolic and immunological alterations during experimental sepsis and in vitro effect on the no synthesis of macrophage stimulated with lipopolysaccharide. 2013. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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