INJURIES OF THE CENTRAL NERVOUS SYSTEM OF DOGS WITH VISCERAL LEISHMANIASIS IS DUE TO THE PRESENCE OF THE PARASITE?

• Grant number: 11/15971-6
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2012
• End date: January 31, 2013
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Mary Marcondes
• Grantee: Cinthya Brillante Cardinot
• Host Institution: Faculdade de Medicina Veterinária (FMVA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

Visceral leishmaniasis is a disease that has a great variability of clinical signs in dogs, among them the occurrence of neurological symptoms, even in the absence of other opportunistic agents. Although some authors have already identified the parasite amastigotes in the central nervous system of dogs with VL, it is unclear whether it directly participates in the development of neurological disorders. Thus, this study aims to search through PCR the presence of DNA of L. chagasi fragments in paraffin central nervous system (frontal cortex, piriform lobe, choroid plexus, lateral ventricle, midbrain, cerebellar peduncles and cerebellum) from two groups of dogs with visceral leishmaniasis. The first group will consist of 18 dogs with clinical evidence of neurological signs and the second group will consist of 18 animals without clinical evidence of neurological signs, totalizing 216 fragments to be evaluated.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CARDINOT, Cinthya Brillante. Identificação de DNA de Leishmania sp. no encéfalo de cães com Leishmaniose visceral. 2013. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Medicina Veterinária. Araçatuba Araçatuba.