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Action of curcumin in angiogenesis in experimental model of breast cancer

Grant number: 11/16528-9
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): December 31, 2012
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Pathology
Principal researcher:Debora Aparecida Pires de Campos Zuccari
Grantee:Lívia Carvalho Ferreira
Home Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil

Abstract

Breast cancer is the most common neoplasm in women being classified as the second most common type of cancer in the world. The tumor growth requires the formation of new vessels that are stimulated by vascular endothelial growth factor (VEGF), expressed under the control of hypoxia-inducible factor - 1± (HIF-1±). Thus, VEGF, its receptors and molecules involved in angiogenesis are a prime target for new therapeutic agents. Some studies have shown that administration of curcumin (a component of the extract of Curcuma longa L) reflected in oncostáticos effects, and can reduce angiogenesis mediated by VEGF and HIF-1± in some tumor types, but this relationship has not been described for breast cancer. The objective of this study is to evaluate the effects of treatment with curcumin on VEGF-mediated angiogenesis in breast cancer in an in vivo study. The molecular and protein expression of VEGF and HIF-1± is verified by real-time PCR and immunohistochemistry, respectively. In addition, there will be the technique of computed tomography single photon emission tomography (SPECT) using Tc-99m agent-HYNIC-VEGF-C that allows the analysis of angiogenesis in animal models. The data obtained in this study may provide probable benefits of the use of curcumin as a therapeutic agent in the treatment of breast cancer, contributing to the growth control and tumor invasion. (AU)

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