The influence of L-glutamine on immunomodulatory aspects of bone marrow mesenchymal stem cells in a malnourishment state

• Grant number: 11/21153-4
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: March 01, 2012
• End date: November 30, 2012
• Field of knowledge: Biological Sciences - Immunology - Applied Immunology
• Principal Investigator: Ricardo Ambrósio Fock
• Grantee: Guilherme Galvão dos Santos
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

According to the World Health Organization, malnourishment is a worldwide health problem that affects approximately 30% of world population in some degree. Malnourishment modifies the production of hematopoietic cells compromising, in this way, immunity. It also influences the capability of mesenchymal stem cells to differentiate in other parenchymal cell types, compromising the generation of a supportive parenchyma necessary for hematopoietic stem cell homeostasis. It is known that glutamine has immunomodulatory properties which benefit immune responses. In pathological conditions, this aminoacid can became essential to the organism. Knowing the importance of mesenchymal stem cells in sustaining hematopoiesis, this work aims to evaluate the influence of glutamine on immunomodulatory properties of mesenchymal stem cells under malnourishment state. In order to accomplish this, we use an experimental in vivo model of malnourishment previously developed in our lab.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SANTOS, Guilherme Galvão dos. The influence of L-glutamine on imunumodulatory aspects of bone marrow mesenchymal stem cells under protein-energy malnutrition. 2015. Doctoral Thesis - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.