Evaluation of biological activity of ent-kaurenoic acid derivatives by biotransformation and semi synthesis

• Grant number: 11/23028-2
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: March 01, 2012
• End date: September 30, 2015
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Sergio Ricardo Ambrosio
• Grantee: Marilia Rodrigues Simão
• Host Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil
• Associated research grant: 07/54762-8 - Obtaining structural analogues of pimaradienoic acid through the process of fungal biotransformation and study of the effect of these metabolites on the activity of the TcDHODH enzyme and on the contraction of the vascular smooth muscle of the aorta artery of mice, AP.BTA.JP

Abstract

The goal of the present project is obtain derivatives from Kaurenoic Acid (KA), a diterpene found in high amounts in the leaves of Mikania glomerata, which is associated with several biological activities, including its antifungal properties. The structural modifications in the chemical skeleton of KA will be performed by biotransformation processes using two different microorganisms, Aspergillus terreus and Penicillium brevicompactum. The obtained metabolites will be evaluated against a panel of phytopathogens responsible for serious agricultural diseases. Moreover, the inhibitory effect on rat aorta contraction of these metabolites will also be investigated. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DA COSTA, RICARDO M.; BASTOS, JAIRO K.; COSTA, MARIA C. A.; FERREIRA, MARCIA M. C.; MIZUNO, CASSIA S.; CARAMORI, GIOVANNI F.; NAGURNIAK, GLAUCIO R.; SIMAO, MARILIA R.; DOS SANTOS, RAQUEL A.; VENEZIANI, RODRIGO C. S.; et al. In vitro cytotoxicity and structure-activity relationship approaches of ent-kaurenoic acid derivatives against human breast carcinoma cell line. Phytochemistry, v. 156, p. 214-223, DEC 2018. (11/13630-7, 11/23028-2, 07/54762-8, 11/07623-8)

SIMAO, MARILIA R.; CARNEIRO, LUIZA J.; DOS SANTOS, RAQUEL A.; BASTOS, JAIRO K.; VENEZIANI, RODRIGO C. S.; AMBROSIO, SERGIO R.; MIZUNO, CASSIA S.. In vitro cytotoxicity study of ent-kaurenoic acid derivatives against human breast carcinoma cell line. MEDICINAL CHEMISTRY RESEARCH, v. 25, n. 2, p. 303-309, FEB 2016. (11/23028-2, 11/13630-7)