Evaluation of angiogenic properties and cardiac effects of new arylidene-thiazolidinediones

• Grant number: 11/24020-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: February 01, 2012
• End date: March 31, 2013
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Dulcineia Saes Parra Abdalla
• Grantee: Renila Ferrer
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 12/08126-0 - Evaluation of two new arylidene-thiazolidinediones effects on stem cell derived cardiomyocytes, BE.EP.IC

Abstract

Thiazolidinedione (TZDs) are drugs widely used for the treatment of patients with type 2 diabetes. Despite its hypoglycemic activity, the TZDs also have pleiotropic effects on the vasculature. Indeed, TZDs, including rosiglitazone and pioglitazone, can inhibit endothelial cell migration and angiogenesis, a process associated with diabetic complications. However, despite the beneficial effects reported with treatment with these compounds, adverse effects are also reported. Importantly, weight gain, increased risk of fractures as well as an increased risk of heart failure are associated with TZD therapy. Therefore, the development of new TZDs with similar beneficial effects and fewer adverse effects is needed. The present study will investigate the effects of two new arylidene-TZDs, called GQ2 and GQ11 in endothelial cells and in cardiomyocytes derived from stem cells. To achieve the goals, models that mimic the different stages of the angiogenic process will be employed. The analysis of the new TZDs effects on the expression of angiogenic genes will also be performed. In addition, the cardiotoxic effect of the new TZDs will be explored in cardiomyocytes derived from stem cells.(AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RUDNICKI, MARTINA; TRIPODI, GUSTAVO L.; FERRER, RENILA; BOSCA, LISARDO; PITTA, MARINA G. R.; PITTA, IVAN R.; ABDALLA, DULCINEIA S. P.. New thiazolidinediones affect endothelial cell activation and angiogenesis. European Journal of Pharmacology, v. 782, p. 98-106, JUL 5 2016. (12/51316-5, 11/24020-5)