Participation of hydrogen sulfide (H2S) on rostral ventrolateral medulla in the modulation of ventilatory responses to hypoxia

• Grant number: 12/01417-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: May 01, 2012
• End date: April 30, 2014
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Luiz Guilherme de Siqueira Branco
• Grantee: Alberto Ferreira Donatti
• Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Hydrogen sulfide (H2S), recently described as the third member of the gaseous neuromodulator, is produced endogenously by metabolic pathways with predominant participation of two enzymes: cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS). In the carotid corpuscle, was described as the presence and participation of CSE generating H2S in response to hypoxia. With respect to the CBS enzyme, this is predominantly found in brain tissue, including the brainstem, a region where are located the main nuclei involved in the control of ventilation and central chemoreception. However, so far not been described the effects of H2S in specific regions of the brainstem involved in respiratory control as the rostral ventrolateral medulla (RVLM). Since we detected the presence of CBS in this region and that little is known about the role of H2S in the ventilatory response, this project aims to evaluate the participation of the gaseous messenger RVLM in modulating ventilatory response to hypoxia.

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SORIANO, RENATO N.; BRAGA, SARA P.; BREDER, JESSICA S. C.; BATALHAO, MARCELO E.; OLIVEIRA-PELEGRIN, GABRIELA R.; FERREIRA, LUIZ FERNANDO R.; ROCHA, MARIA JOSE A.; CARNIO, EVELIN C.; BRANCO, LUIZ G. S.. Endogenous peripheral hydrogen sulfide is propyretic: its permissive role in brown adipose tissue thermogenesis in rats. Experimental Physiology, v. 103, n. 3, p. 397-407, MAR 1 2018. (16/17681-9, 12/01417-0, 15/24950-3)

DONATTI, ALBERTO FERREIRA; SORIANO, RENATO NERY; ANDRADE LEITE-PANISSI, CHRISTIE RAMOS; BRANCO, LUIZ G. S.; DE SOUZA, ALBERT SCHIAVETO. Anxiolytic-like effect of hydrogen sulfide (H2S) in rats exposed and re-exposed to the elevated plus-maze and open field tests. Neuroscience Letters, v. 642, p. 77-85, MAR 6 2017. (12/01417-0)

DONATTI, ALBERTO F.; SORIANO, RENATO N.; SABINO, JOAO P.; BRANCO, LUIZ G. S.. Involvement of endogenous hydrogen sulfide (H2S) in the rostral ventrolateral medulla (RVLM) in hypoxia-induced hypothermia. Brain Research Bulletin, v. 108, p. 94-99, SEP 2014. (12/01417-0)

DONATTI, ALBERTO F.; ARAUJO, REBECA M.; SORIANO, RENATO N.; AZEVEDO, LEOPOLDO U.; LEITE-PANISSI, CHRISTIE A.; BRANCO, LUIZ G. S.. Role of hydrogen sulfide in the formalin-induced orofacial pain in rats. European Journal of Pharmacology, v. 738, p. 49-56, SEP 5 2014. (12/13888-7, 12/01417-0, 13/12850-9)

DONATTI, ALBERTO F.; SORIANO, RENATO N.; SABINO, JOAO P.; BRANCO, LUIZ G. S.. Endogenous hydrogen sulfide in the rostral ventrolateral medulla/Botzinger complex downregulates ventilatory responses to hypoxia. Respiratory Physiology & Neurobiology, v. 200, p. 97-104, AUG 15 2014. (12/01417-0)