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Effects of hydrogen sulphide (H2S) on in vitro (pre-Botzinger medullary slice) inpiratory rhythm generation

Grant number: 12/02413-8
Support type:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): August 01, 2012
Effective date (End): January 31, 2013
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:Luiz Guilherme de Siqueira Branco
Grantee:Glauber dos Santos Ferreira da Silva
Supervisor abroad: Gregory Douglas Funk
Home Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Local de pesquisa : University of Alberta, Canada  

Abstract

Hydrogen sulfide (H2S) has recently been considered an additional endogenous gasotransmitter and within the central nervous system, H2S is predominantly produced by the enzyme cystathionine-B-synthase (CBS). CBS-produced H2S may regulate the cardiorespiratory system and modulate peripheral chemoreceptor sensory afferents that project to the NTS, as well as the ventilatory response to a brief hypoxic challenge. H2S augments synaptic transmission between visceral afferents and second-order neurons in the NTS via mechanisms at the presynaptic terminal, including enhancement in intracellular calcium, rather than altering postsynaptic properties. To date, the effect of H2S on other respiratory-related regions in the brainstem is not known. Mainly the role of H2S in the medullary respiratory network, especially its action in the inspiratory rhythm generation centre (the preBotzinger complex) remains unknown. Therefore, the objective of the present project is to study in vitro the effects of exogenous (by application of H2S donor) and endogenous (by inhibiting H2S production via CBS/CSE) H2S on inspiratory rhythm generation in the preBötzinger complex (preBötC), using medullary slices that generate spontaneous inspiratory-related oscillations in vitro. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVA, GLAUBER S. F.; SABINO, JOAO P. J.; RAJANI, VISHAAL; ALVARES, TUCAAUE S.; PAGLIARDINI, SILVIA; BRANCO, LUIZ G. S.; FUNK, GREGORY D. Excitatory Modulation of the preBotzinger Complex Inspiratory Rhythm Generating Network by Endogenous Hydrogen Sulfide. FRONTIERS IN PHYSIOLOGY, v. 8, JUN 30 2017. Web of Science Citations: 1.

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