ASSESSMENT OF RESISTANCE TO CHEMICAL, MECHANICAL AND BIOLOGICAL DEGRADATION OF EXPERIMENTAL INFILTRANTS FOLLOWED SOLUBILITY AND CYTOTOXICITY TESTS

• Grant number: 11/22149-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: April 01, 2012
• End date: August 02, 2015
• Field of knowledge: Health Sciences - Dentistry - Dental Materials
• Principal Investigator: Fernanda Miori Pascon
• Grantee: Luciana Tiemi Inagaki
• Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil

Abstract

The caries lesions development in suitable sites for biofilm deposits as interproximal, gingival margin and occlusal surfaces. The arrest of incipient caries in these areas by light curing infiltrant materials is an alternative to a less invasive dentistry. The pores of enamel caries act as a pathway for the diffusion of acids and dissolved minerals. The blockage of pores by materials of low viscosity and high penetration stops the progression of caries lesions and mechanically stabilize the fragile structure of the compromised enamel. The different chemical means coming into contact with oral structures associated with brushing mechanisms affect the surface hardness and roughness of the teeth and restorations. The chemical degradation increases the surface roughness of restorative materials and their hardness changes providing a greater accumulation of plaque and hence its biodegradation surface. The addition of an antibacterial agent such as chlorhexidine diacetate (CHX) in infiltrants can lessen or prevent the adhesion of biofilm on the surface of the material, avoiding new caries lesions in adjacent healthy enamel. However, due to the mechanism of sorption and solubility of resin materials in the interaction with the oral environment, residual monomer particles and CHX can leach from the polymer matrix and change the physical and mechanical properties of these materials. This research project aims to: (1) evaluate the surface hardness and roughness of nine experimental mixtures with infiltrating features, which are basic components as the monomers TEGDMA, UDMA and BISEMA after processes of chemical degradation and biodegradation, followed by degradation by mechanical brushing, (2) evaluate the sorption and solubility of experimentals resin mixtures; (3) evaluate the biocompatibility of materials through experimental test of cytotoxicity. The results may contribute to the development of great use dental materials in the pediatric and preventive programs.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

INAGAKI, LUCIANA TIEMI; DAINEZI, VANESSA BENETELLO; BRUSCHI ALONSO, ROBERTA CAROLINE; DE PAULA, ANDRELA BOLZAN; GARCIA-GODOY, FRANKLIN; PUPPIN-RONTANI, REGINA MARIA; PASCON, FERNANDA MIORI. Evaluation of sorption/solubility, softening, flexural strength and elastic modulus of experimental resin blends with chlorhexidine. Journal of Dentistry, v. 49, p. 40-45, JUN 2016. (11/22149-0)

INAGAKI, LUCIANA TIEMI; BRUSCHI ALONSO, ROBERTA CAROLINE; SPAGNOLO ARAUJO, GIOVANA ALBAMONTE; CARUALHO DE SOUZA-JUNIOR, EDUARDO JOSE; ANIBAL, PAULA CRISTINA; HOFLING, JOSE FRANCISCO; PASCON, FERNANDA MIORI; PUPPIN-RONTANI, REGINA MARIA. Effect of monomer blend and chlorhexidine-adding on physical, mechanical and biological properties of experimental infiltrants. Dental Materials, v. 32, n. 12, p. E307-E313, DEC 2016. (10/01010-1, 11/22149-0, 10/20254-9)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

INAGAKI, Luciana Tiemi. Evaluation of physical-chemical properties of experimental infiltrants chlorhexidine-added. 2016. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba Piracicaba, SP.