Evaluation of heat stress on the development of necrotic enteritis due to Clostridium perfringens in broilers

• Grant number: 12/03103-2
• Support Opportunities: Scholarships in Brazil - Master
• Start date: May 01, 2012
• End date: July 31, 2013
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Pathology
• Principal Investigator: João Palermo Neto
• Grantee: Atilio Sersun Calefi
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 09/51886-3 - Neuroimmunomodulation: drugs, stress and cytokines on nervous, endocrine and immune systems relationships, AP.TEM

Abstract

The meat of poultry has been prominent in recent years as food for their protein quality and affordable price. The poultry industry has the highest growth in production volume from all other meat sectors in Brazil. Thus, the poultry industry has gained increasing importance in applied research in major research centers. Because of this great interest in food and thinking about the risk to public health, recently the European Union (EU) banned the use of prophylactic antimicrobial additives in animal feed. With that and coupled with intensive raising system in poultry, previously controlled diseases have become reemerging, one of the most important and reemerging diseases of great concern in Brazil and UE is the avian necrotic enteritis (NE). NE is a disease that affects poultry at 2-6 weeks of life, its primary etiologic agent is Clostridium perfringens, a gram positive, toxigenic, spore-forming anaerobic and growth. It is estimated that the worldwide loss due to subclinical necrotic enteritis exceed $ 2 billion. Studies show that stress has a huge importance in the development of NE, but little is known about what modulates this development. Considering Brazil is a subtropical country, supports the premise that studies focusing on aspects of neuroimmune relationships in broiler chickens subjected to heat stress are important for directing rational grounds for reversal of any changes triggered by heat in particular in the intestinal mucosa of animals. Among them, particular attention NE gains, since the heat stress possibly triggering the onset of disease.

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

AS CALEFI; WM QUINTEIRO-FILHO; AR FUKUSHIMA; DSG DA CRUZ; A DE SIQUEIRA; FA SALVAGNI; LB NAMAZU; COMS GOMES; AJP FERREIRA; J PALERMO NETO. Dexamethasone Regulates Macrophage and Cd4+Cd25+ Cell Numbers in the Chicken Spleen. Brazilian Journal of Poultry Science, v. 18, n. 1, p. 93-100, 2016-03-00. (12/03103-2, 09/51886-3, 13/17408-2)

CALEFI, A. S.; QUINTEIRO-FILHO, W. M.; FERREIRA, A. J. P.; PALERMO-NETO, J.. Neuroimmunomodulation and heat stress in poultry. WORLDS POULTRY SCIENCE JOURNAL, v. 73, n. 3, p. 493-504, SEP 2017. (12/03103-2, 13/17408-2, 09/51886-3)

CALEFI, ATILIO SERSUN; DA SILVA FONSECA, JULIANA GARCIA; HAMADA COHN, DANIEL WAGNER; BUENO HONDA, BRUNO TAKASHI; COSTOLA-DE-SOUZA, CAROLINA; TSUGIYAMA, LUCILA EMIKO; QUINTEIRO-FILHO, WANDERLEY MORENO; PIANTINO FERREIRA, ANTONIO J.; PALERMO-NETO, JOAO. The gut-brain axis interactions during heat stress and avian necrotic enteritis. POULTRY SCIENCE, v. 95, n. 5, p. 1005-1014, MAY 2016. (12/03103-2, 13/17408-2, 09/51886-3)

CALEFI, ATILIO SERSUN; BUENO HONDA, BRUNO TAKASHI; COSTOLA-DE-SOUZA, CAROLINA; DE SIQUEIRA, ADRIANA; NAMAZU, LILIAN BERNADETE; QUINTEIRO-FILHO, WANDERLEY MORENO; DA SILVA FONSECA, JULIANA GARCIA; ARRAIS ALOIA, THIAGO PINHEIRO; PIANTINO-FERREIRA, ANTONIO JOSE; PALERMO-NETO, JOAO. Effects of long-term heat stress in an experimental model of avian necrotic enteritis. POULTRY SCIENCE, v. 93, n. 6, p. 1344-1353, JUN 2014. (12/03103-2, 09/51886-3)

CALEFI, ATILIO SERSUN; DE QUEIROZ NUNES, CATARINA AUGUSTA; DA SILVA FONSECA, JULIANA GARCIA; QUINTEIRO-FILHO, WANDERLEY MORENO; PIANTINO FERREIRA, ANTONIO JOSE; PALERMO-NETO, JOAO. Heat stress reduces Eimeria spp. infection and interferes with C. perfringens infection via activation of the hypothalamic-pituitary-adrenal axis. Research in Veterinary Science, v. 123, p. 273-280, APR 2019. (12/03103-2, 13/17408-2, 09/51886-3)

CALEFI, ATILIO SERSUN; QUINTEIRO-FILHO, WANDERLEY MORENO; DE SIQUEIRA, ADRIANA; NASCIMENTO LIMA, ANA PAULA; GIMENES CRUZ, DANIEL SANZIO; HAZARBASSANOV, NICOLLE QUEIROZ; SALVAGNI, FERNANDO AUCIELLO; BORSOI, ANDERLISE; MASSOCO SALLES GOMES, CRISTINA DE OLIVEIRA; MAIORKA, PAULO CESAR; et al. Heat stress, Eimeria spp. and C. perfringens infections alone or in combination modify gut Th1/Th2 cytokine balance and avian necrotic enteritis pathogenesis. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, v. 210, p. 28-37, APR 2019. (12/03103-2, 13/17408-2, 09/51886-3)

CALEFI, A. S.; QUINTEIRO-FILHO, W. M.; FUKUSHIMA, A. R.; DA CRUZ, D. S. G.; DE SIQUEIRA, A.; SALVAGNI, F. A.; NAMAZU, L. B.; GOMES, C. O. M. S.; FERREIRA, A. J. P.; PALERMO NETO, J.. Dexamethasone Regulates Macrophage and Cd4+Cd25+Cell Numbers in the Chicken Spleen. Brazilian Journal of Poultry Science, v. 18, n. 1, p. 93-99, JAN-MAR 2016. (13/17408-2, 12/03103-2, 09/51886-3)

CALEFI, ATILIO SERSUN; DE SIQUEIRA, ADRIANA; NAMAZU, LILIAN BERNADETE; COSTOLA-DE-SOUZA, CAROLINA; TAKASHI HONDA, BRUNO BUENO; PIANTINO FERREIRA, ANTONIO JOSE; QUINTEIRO-FILHO, WANDERLEY MORENO; DA SILVA FONSECA, JULIANA GARCIA; PALERMO-NETO, JOAO. Effects of heat stress on the formation of splenic germinal centres and immunoglobulins in broilers infected by Clostridium perfringens type A. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, v. 171, p. 38-46, MAR 2016. (12/03103-2, 13/17408-2, 09/51886-3)

CALEFI, ATILIO SERSUN; DA SILVA FONSECA, JULIANA GARCIA; DE QUEIROZ NUNES, CATARINA AUGUSTA; NASCIMENTO LIMA, ANA PAULA; QUINTEIRO-FILHO, WANDERLEY MORENO; FLORIO, JORGE CAMILO; ZAGER, ADRIANO; PIANTINO FERREIRA, ANTONIO JOSE; PALERMO-NETO, JOAO. Heat Stress Modulates Brain Monoamines and Their Metabolites Production in Broiler Chickens Co-Infected with Clostridium perfringens Type A and Eimeria spp.. VETERINARY SCIENCES, v. 6, n. 1, p. 14-pg., 2019-03-01. (09/51886-3, 13/17408-2, 12/03103-2)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CALEFI, Atilio Sersun. Evaluation of heat stress on Clostridium perfringens infection in broiler chickens. 2013. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ/SBD) São Paulo.