Analysis of expression and action of cytotoxic molecules in T lymphocytes during the evolution of Experimental Autoimmune Neuritis

• Grant number: 12/07133-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: May 01, 2012
• End date: April 30, 2013
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Alessandro dos Santos Farias
• Grantee: Renata Zanetti Morelli
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 11/18728-5 - Study of migratory, effector and regulatory pattern of autoreactive t lymphocytes, previously transduced with GFP in experimental demyelinating diseases, AP.JP

Abstract

The Experimental Autoimmune Neuritis (EAE) is considered the experimental model of Guillain-Barre syndrome. The EAN is a disease of autoimmune character characterized by the invasion of mononuclear cells in the endoneurial space. Autoreactive T cells are activated and respond to peripheral myelin components. This response is mediated mainly by Th1 lymphocytes and/or TH17. Nevertheless, it is unclear how T cells with helper functions would have the capacity to begin the inflammatory process. Our preliminary data indicate that encephalitogenic and neuritogenic T cells express unusual quantities, for T CD4+ cells, of molecules with cytotoxic action. Therefore, in this project is our goal to study the expression and action of cytotoxic molecules during the clinical evolution of EAN.(AU)