Anatomic projections between retrotrapezoid nucleus and caudal ventral respiratory group

• Grant number: 12/03568-5
• Support Opportunities: Scholarships in Brazil - Master
• Start date: July 01, 2012
• End date: June 30, 2014
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Ana Carolina Thomaz Takakura
• Grantee: Josiane do Nascimento Silva
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 10/09776-3 - Neural mechanisms involved in expiratory rhythm generator: possible involvement of the retrotrapezoid nucleus and the parafacial region, AP.JP

Abstract

The eupnoeic pattern of respiration consists of three phases: inspiration, post-inspiration (passive expiration, stage 1) and stage 2 of expiration. These studies demonstrated that, during respiration, phasic discharges are generated within the ventral respiratory column without the need for peripheral feedback, involving a neuronal network co-ordinated by synaptic interactions (Smith and cols., 1991) that was called ventral respiratory column. Moreover the neural mechanisms for respiratory control are carefully organized by a complex neuron system localized into the medulla oblongata. This system is highly sensitive to CO2 and maintains the CO2 and O2 in the blood into physiological level, controlling the ventilation cycle by cycle. During breathing at rest, air is expired passively by recoil forces. Augmenting expiratory activity during the second phase of expiration (E2) is always present in the brainstem during eupnoea. An expressed phasic expiratory activity in this motor outflow is observed only during increased ventilatory demand such as during exercise in man (Abraham and cols., 2002), hipercapnia or hypoxia in the cat (Fregosi and Bartlett, 1988, Fregosi, 1994, Iizuka and Fregosi, 2007). Recent evidences suggest the involvement of chemosensitive neurons of the retrotrapezoid nucleus (RTN) in the control of expiratory activity of premotor neurons of the caudal ventral respiratory group. In this way, the aim of this project is to investigate the existence of an anatomical projection from RTN to caudal ventral respiratory group neurons and the phenotype of the neurotransmitters involved in this projection. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SILVA, JOSIANE N.; LUCENA, ELVIS V.; SILVA, TALITA M.; DAMASCENO, ROSELIA S.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.. INHIBITION OF THE PONTINE KOLLIKER-FUSE NUCLEUS REDUCES GENIOGLOSSAL ACTIVITY ELICITED BY STIMULATION OF THE RETROTRAPEZOID CHEMORECEPTOR NEURONS. Neuroscience, v. 328, p. 9-21, JUL 22 2016. (12/03568-5, 10/09776-3, 13/10573-8, 09/54888-7, 13/00401-5, 10/15692-7, 12/16166-2)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SILVA, Josiane do Nascimento. Anatomofuctional evidences that retrotrapezoid nucleus regulates active expiration.. 2014. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.