Action of the immunomodulator P-MAPA on the complement system and Toll like receptors in a model of inflammation induced by LPS

• Grant number: 12/05306-8
• Support Opportunities: Scholarships in Brazil - Master
• Effective date (Start): July 01, 2012
• Effective date (End): December 31, 2013
• Field of knowledge: Biological Sciences - Immunology - Immunochemistry
• Principal Investigator: Denise Vilarinho Tambourgi
• Grantee: Mariana Torrente Gonçalves
• Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated research grant: 08/57898-0 - National Institute of Science and Technology on Toxins, AP.TEM

Abstract

Initially conceived as an antitumoral compound, the P-MAPA (polymeric anhydride of magnesium and proteic ammonium phospholinoleate) presented immunomodulatory potential in several studies, concerning cytokines secretion, NFºB expression and nitric oxide production by macrophages. However, it's action on elements from innate immunity, such as the complement system and Toll like receptors are still unknown, although there are evidences that P-MAPA may act upon those receptors. Thereby, the present study proposes evaluate the possible modulatory role of P-MAPA upon the complement system and Toll like receptors, using an inflammation model induced by E. coli LPS, in human whole blood in vitro.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DURAN, NELSON; FAVARO, WAGNER J.. BIOGENIC SYNTHESIS OF IMPORTANT ENVIRONMENTAL MINERALS: MAGNESIUM PHOSPHATE COMPOUNDS AND PERSPECTIVES. Química Nova, v. 41, n. 5, p. 567-576, MAY 2018. (15/20767-0, 14/12047-4, 11/05919-7, 09/50426-9, 12/19741-8, 15/00423-4, 16/03993-9, 14/08549-4, 99/06052-3, 12/13585-4, 12/05306-8, 13/01600-1, 12/11002-1, 13/10520-1, 16/07393-6, 13/11082-8, 13/10521-8, 11/05726-4, 13/11346-5, 14/11866-1, 11/03774-1, 12/16880-7)

GONCALVES, MARIANA TORRENTE; SQUAIELLA-BAPTISTAO, CARLA CRISTINA; PIDDE, GISELLE; LOPES, PRISCILA HESS; DA SILVA NUNES, ISEU; TAMBOURGI, DENISE V.. P-MAPA, a Fungi-Derived Immunomodulatory Compound, Induces a Proinflammatory Response in a Human Whole Blood Model. Mediators of Inflammation, v. 2020, NOV 24 2020. (13/07467-1, 12/05306-8)

DURAN, NELSON; FAVARO, WAGNER J.. BIOGENIC SYNTHESIS OF IMPORTANT ENVIRONMENTAL MINERALS: MAGNESIUM PHOSPHATE COMPOUNDS AND PERSPECTIVES. Química Nova, v. 41, n. 5, p. 10-pg., 2018-05-01. (14/11866-1, 14/12047-4, 12/19741-8, 12/16880-7, 13/10521-8, 15/20767-0, 14/08549-4, 11/05919-7, 09/50426-9, 11/05726-4, 12/13585-4, 13/10520-1, 15/00423-4, 11/03774-1, 16/03993-9, 12/11002-1, 13/11346-5, 99/06052-3, 13/11082-8, 13/01600-1, 12/05306-8, 16/07393-6)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

GONÇALVES, Mariana Torrente. Action of the immunomodulator P-MAPA on the complement system and Toll like receptors in a model of inflammation induced by lipopolysaccharide.. 2014. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.