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National Institute of Science and Technology on Toxins

Grant number: 08/57898-0
Support type:Research Projects - Thematic Grants
Duration: March 01, 2009 - February 29, 2016
Field of knowledge:Biological Sciences - Immunology
Cooperation agreement: CNPq - INCTs
Principal researcher:Osvaldo Augusto Brazil Esteves Sant'Anna
Grantee:Osvaldo Augusto Brazil Esteves Sant'Anna
Home Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Associated grant(s):15/19297-9 - Multi-user equipment approved in grant 2008/57898-0: CYTATION 3, AP.EMU
Associated scholarship(s):12/07112-6 - Structural and functional studies with Bothropstoxin-I, from Bothrops jararacussu snake venom, and caffeic acid derivates, BP.DR
12/05306-8 - Action of the immunomodulator P-MAPA on the complement system and Toll like receptors in a model of inflammation induced by LPS, BP.MS
12/00428-8 - Structural and Functional Characterization of Crotoxin and its Basic Subunit in the Neuromuscular Junction and Influence of Neutralizing Agents, BP.PD
+ associated scholarships 12/03308-3 - Characterization and phylogenetic analysis of genes coding for C3 and factor B complement system components from Loxosceles spiders, BP.DD
10/06345-1 - Study of factors involved in lipid bodies formation induced by a Phospholipase A2, isolated from Bothrops asper snake venom: synthesis and metabolism of lipids, BP.DR
09/11490-3 - Clonning and characterization of C3-like and Factor B-like complement genes from Loxosceles laeta spiders venom gland, BP.MS - associated scholarships


The central objective of the National Institute of Science and Technology on Toxins [NISTTOX] is founded in the creation of a nucleus in a strategic area of scientific knowledge in the basic disciplines, developing immunobiologicals and biopharmaceutical products in Brazil. It also has the aim of rationalizing the utilization of existing facilities or the building new structures in which, based on the projects presented in the sub-programs by the teams committed to this plan, multiplications will be carried out in the formation of human resources and execution of coordinated works. Since the 1960s, disciplines such as immunology, pharmacology, biochemistry, molecular biology and, more recently, physiopathology and toxicology, have gained major importance in biomedical sciences and medical practice, especially due to the accumulated knowledge from answers to questions regarding immunity, local actions, and neuro and hematoxicity, in the broad sense. Because of its original vocation started with Vital Brazil, the Butantan Institute, headquarters of the present project, continues with the development of processes and products associated with these areas of knowledge, as the basis of its scientific research. Today, more than ever, with the unique opportunity that this CNPq Edictal offers, the works carried out by the associated laboratories will be able to exercise and crystallize the principle that the generation of knowledge does not come from its competitive essence or from individualistic endeavor, but from a collective work in the conceptions and evaluations proposed by the nucleus of scientific investigators/professors of teams at renown institutions such as UFMG, FIOCRUZ, UENF, UNICAMP, UNESP, UFPA, UFAM, Museu GOELDI, USP, FUNED, UFRJ and Butantan, which give form to this project, The consent letters of all the scientists are under the ownership of coordinator of this project. In addition, this project can contribute to eliminating the obscurity caused by the fragmentation of biological knowledge in the general sense. It is viewed as an excellent opportunity for the study of correlations associated with the complexities of the actions of venoms and the gamut of molecular interactions that lead to our understanding of diversity, species, and survival. Moreover, a program of f1exible research can be constructed, involving the training of young investigators, taking into account the epidemiology already known of the accidents caused by poisonous animals. The biological questions relative to the concepts of venoms and toxins of different species on the one hand, and cell receptors or effectors molecules of immune responses or reagents of pharmacological or physiopathological processes on the other will be introduced to modernity which always represented the principle of evolution. The general concepts of complexity, variability and specificity, should be contemplated for better understanding of organisms. Thus, the evolutionary directions, and not only the functional aspect of toxins, were prioritized, and the endogenous expressions resulting from the interactions of toxins and biological actions will form the basis of integrated analyses of studies. This proposal is founded on the quantitative and qualitative actions of toxins, of bio¬prospecting, of immunity and innate or acquired resistance, and of processes of envenomation and therapeutic response. It is aimed at consolidating groups of recognized scientific-teaching capability, structure an indispensable socio-educational commitment, contemplating innovation, development of products and processes, and publication of findings and knowledge, and connecting with and supporting an emerging center in north Brazil. This center is the future Federal University of West Para, which will be established in Santarem; this municipality is located on the banks of the Tapajos, Arapiuns and Amazon Rivers and will be one of the bases for collections and studies. The project is structured into the following sub-programs: Immunology, Physiopathology, Biochemistry and Molecular Biology, Biodiversity and evolution actions in health [education, production]; actions in Amazonia; translational research [innovation]... (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
Allies for an antidotal serum 
São Paulo en la Amazonia 
São Paulo in the Amazon region 
Venoms in the forest 
Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
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Scientific publications (22)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
KIMURA, L. F.; SANTOS-NETO, M.; BARBARO, K. C.; PICOLO, G.. Potamotrygon motoro stingray venom induces both neurogenic and inflammatory pain behavior in rodents. Toxicon, v. 150, p. 168-174, . (08/57898-0, 12/00166-3)
TAVORA, BIANCA C. L. F.; KIMURA, LOUISE F.; ANTONIAZZI, MARTA M.; CHIARIELLO, THIAGO M.; FAQUIM-MAURO, ELIANA L.; BARBARO, KATIA C.. Involvement of mast cells and histamine in edema Scolopendra viridicornis centipede venom. Toxicon, v. 121, p. 51-60, . (08/57898-0)
STUGINSKI, DANIEL RODRIGUES; NAVAS, CARLOS ARTURO; DE BARROS, FABIO CURY; CAMACHO, AGUSTIN; PEREIRA WILKEN BICUDO, JOSE EDUARDO; GREGO, KATHLEEN FERNANDES; DE CARVALHO, JOSE EDUARDO. Phylogenetic analysis of standard metabolic rate of snakes: a new proposal for the understanding of interspecific variation in feeding behavior. JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL, v. 188, n. 2, p. 315-323, . (08/57712-4, 08/57687-0, 12/15754-8, 08/57898-0)
GIANNOTTI, KARINA CRISTINA; LEIGUEZ, ELBIO; ZULIM DE CARVALHO, ANA EDUARDA; NASCIMENTO, NEIDE GALVAO; MATSUBARA, MARCIO HIDEKI; FORTES-DIAS, CONSUELO LATORRE; MOREIRA, VANESSA; TEIXEIRA, CATARINA. A snake venom group IIA PLA2 with immunomodulatory activity induces formation of lipid droplets containing 15-d-PGJ(2) in macrophages. SCIENTIFIC REPORTS, v. 7, . (13/22610-5, 08/57898-0, 11/21341-5)
MOREIRA, VANESSA; MAGGIO DE CASTRO SOUTO, POLLYANA CRISTINA; RAMIREZ VINOLO, MARCO AURELIO; LOMONTE, BRUNO; GUTIERREZ, JOSE MARIA; CURI, RUI; TEIXEIRA, CATARINA. A catalytically-inactive snake venom Lys49 phospholipase A(2) homolog induces expression of cyclooxygenase-2 and production of prostaglandins through selected signaling pathways in macrophages. European Journal of Pharmacology, v. 708, n. 1-3, p. 68-79, . (10/07630-1, 07/03337-5, 08/57898-0)
COSTA, E. S.; FAIAD, O. J.; LANDGRAF, R. G.; FERREIRA, A. K.; BRIGATTE, P.; CURI, R.; CURY, Y.; SAMPAIO, S. C.. Involvement of formyl peptide receptors in the stimulatory effect of crotoxin on macrophages co-cultivated with tumour cells. Toxicon, v. 74, p. 167-178, . (08/57898-0)
CURY, YARA; PICOLO, GISELE; GUTIERREZ, VANESSA PACCIARI; FERREIRA, SERGIO HENRIQUE. Pain and analgesia: The dual effect of nitric oxide in the nociceptive system. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 25, n. 3, p. 243-254, . (08/57898-0)
GUTIERREZ, VANESSA P.; ZAMBELLI, VANESSA O.; PICOLO, GISELE; CHACUR, MARUCIA; SAMPAIO, SANDRA C.; BRIGATTE, PATRICIA; KONNO, KATSUHIRO; CURY, YARA. The peripheral L-arginine-nitric oxide-cyclic GMP pathway and ATP-sensitive K+ channels are involved in the antinociceptive effect of crotalphine on neuropathic pain in rats. Behavioural Pharmacology, v. 23, n. 1, p. 14-24, . (98/14307-9, 07/00135-2, 07/02478-4, 08/57898-0)
JARED, SIMONE G. S.; JARED, CARLOS; EGAMI, MIZUE I.; MAILHO-FONTANA, PEDRO L.; RODRIGUES, MIGUEL T.; ANTONIAZZI, MARTA M.. Functional assessment of toad parotoid macroglands: A study based on poison replacement after mechanical compression. Toxicon, v. 87, p. 92-103, . (08/57898-0)
ZAMBELLI, VANESSA OLZON; DE OLIVEIRA FERNANDES, ANA CAROLINA; GUTIERREZ, VANESSA PACCIARI; BATISTA FERREIRA, JULIO CESAR; PARADA, CARLOS AMILCAR; MOCHLY-ROSEN, DARIA; CURY, YARA. Peripheral Sensitization Increases Opioid Receptor Expression and Activation by Crotalphine in Rats. PLoS One, v. 9, n. 3, . (07/00135-2, 08/57898-0)
BRIGATTE, PATRICIA; KONNO, KATSUHIRO; GUTIERREZ, VANESSA PACCIARI; SAMPAIO, SANDRA COCCUZZO; ZAMBELLI, VANESSA OLZON; PICOLO, GISELE; CURI, RUI; CURY, YARA. Peripheral kappa and delta opioid receptors are involved in the antinociceptive effect of crotalphine in a rat model of cancer pain. Pharmacology Biochemistry and Behavior, v. 109, p. 1-7, . (98/14307-9, 08/57898-0)
MACHADO, F. C.; ZAMBELLI, V. O.; FERNANDES, A. C. O.; HEIMANN, A. S.; CURY, Y.; PICOLO, G.. Peripheral interactions between cannabinoid and opioid systems contribute to the antinociceptive effect of crotalphine. British Journal of Pharmacology, v. 171, n. 4, SI, p. 961-972, . (09/14203-5, 08/57898-0, 10/12917-8)
KIMURA, LOUISE FAGGIONATO; SANT'ANNA, MORENA BRAZIL; ZAMBELLI, VANESSA OLZON; GIARDINI, ALINE CAROLINA; SILVA JARED, SIMONE GONCALVES; ANTONIAZZI, MARTA MARIA; DE MOURA MATTARAIA, VANIA GOMES; PAGANO, ROSANA LIMA; PICOLO, GISELE. Early exposure to environmental enrichment protects male rats against neuropathic pain development after nerve injury. Experimental Neurology, v. 332, . (13/07467-1, 08/57898-0, 13/20795-8)
OLMEDO, HIDEKEL; HERRERA, MARIA; ROJAS, LEONARDO; VILLALTA, MAUREN; VARGAS, MARIANGELA; LEIGUEZ, ELBIO; TEIXEIRA, CATARINA; ESTRADA, RICARDO; MARIA GUTIERREZ, JOSE; LEON, GUILLERMO; et al. Comparison of the adjuvant activity of aluminum hydroxide and calcium phosphate on the antibody response towards Bothrops asper snake venom. JOURNAL OF IMMUNOTOXICOLOGY, v. 11, n. 1, p. 44-49, . (08/57898-0)
BRESSAN, ELISANGELA; TOUSKA, FILIP; VETTER, IRINA; KISTNER, KATRIN; KICHKO, TATJANA I.; TEIXEIRA, NATHALIA B.; PICOLO, GISELE; CURY, YARA; LEWIS, RICHARD J.; FISCHER, MICHAEL J. M.; et al. Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia. Pain, v. 157, n. 11, p. 2504-2516, . (08/57898-0, 12/51458-4, 13/07467-1, 98/14307-9)
SANT'ANNA, MORENA BRAZIL; RIBEIRO LOPES, FLAVIA SOUZA; KIMURA, LOUISE FAGGIONATO; GIARDINI, ALINE CAROLINA; SANT'ANNA, OSVALDO AUGUSTO; PICOLO, GISELE. Crotoxin Conjugated to SBA-15 Nanostructured Mesoporous Silica Induces Long-Last Analgesic Effect in the Neuropathic Pain Model in Mice. TOXINS, v. 11, n. 12, . (14/19397-0, 17/17844-8, 08/57898-0, 15/01254-1)
PIMENTA, LUCIANA DE ARAUJO; DE ALMEIDA, MAIRA ESTANISLAU S.; BRETONES, MARISA LANGEANI; CIRILLO, MARIA CRISTINA; CURI, RUI; SAMPAIO, SANDRA COCCUZZO. Crotoxin promotes macrophage reprogramming towards an antiangiogenic phenotype. SCIENTIFIC REPORTS, v. 9, . (13/17190-7, 08/57898-0, 12/51241-5)
KIMURA, LOUISE FAGGIONATO; DE MOURA MATTARAIA, VANIA GOMES; PICOLO, GISELE. Distinct environmental enrichment protocols reduce anxiety but differentially modulate pain sensitivity in rats. Behavioural Brain Research, v. 364, p. 442-446, . (08/57898-0, 13/20795-8, 11/17974-2)
LOPES, PRISCILA HESS; MURAKAMI, MARIO T.; PORTARO, V, FERNANDA C.; MESQUITA PASQUALOTO, KERLY FERNANDA; VAN DEN BERG, CARMEN; TAMBOURGI, V, DENISE. Targeting Loxosceles spider Sphingomyelinase D with small-molecule inhibitors as a potential therapeutic approach for loxoscelism. Journal of Enzyme Inhibition and Medicinal Chemistry, v. 34, n. 1, p. 310-321, . (13/07467-1, 08/57898-0, 15/17053-5)
STUGINSKI, DANIEL RODRIGUES; NAVAS, CARLOS ARTURO; DE BARROS, FABIO CURY; GREGO, KATHLEEN FERNANDES; MARTINS, MARCIO; DE CARVALHO, JOSE EDUARDO. The Role of Feeding Specialization on Post-Prandial Metabolic Rate in Snakes of the Genus Bothrops. ZOOLOGICAL SCIENCE, v. 35, n. 4, p. 373-381, . (11/50206-9, 08/57898-0, 08/57712-4, 08/57687-0)

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