Advanced search
Start date
Betweenand

Native and recombinant animal toxins: functional, structural and molecular analysis

Grant number: 11/23236-4
Support type:Research Projects - Thematic Grants
Duration: February 01, 2014 - April 30, 2019
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Suely Vilela
Grantee:Suely Vilela
Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Co-Principal Investigators:Antonio Cardozo dos Santos ; Eliane Candiani Arantes Braga ; Fabíola Attié de Castro ; Maria Cristina Nonato Costa
Assoc. researchers:Antonio José da Costa Filho ; Benedito Barraviera ; Carlos Henrique Tomich de Paula da Silva ; Catarina de Fatima Pereira Teixeira ; Fabiani Gai Frantz ; Fabíola Attié de Castro ; Hamilton Cabral ; José César Rosa ; Lúcia Helena Faccioli ; Luciana Simon Pereira Crott ; Lucilene Delazari dos Santos ; Lusânia Maria Greggi Antunes ; Maria Cristina Nonato Costa ; Maria Regina Torqueti ; Rui Seabra Ferreira Junior ; Sergio Akira Uyemura
Associated grant(s):18/23389-4 - Multi-User Equipment approved in grant 2011/23236-4: prominence chromatography system and accessories, AP.EMU
15/02506-4 - Multi-User Equipment approved in grant 2011/23236-4: automatic sequencing of proteins and peptides, PPSQ-33A model and accessories, AP.EMU
14/20212-5 - Multi-User Equipment approved in grant 2011/23236-4: Labchip GXII touch 24 instrument, AP.EMU
Associated scholarship(s):17/03580-9 - Biochemical, structural and functional evaluation of a phosphodiesterase from Crotalus durissus collilineatus venom, BP.DR
16/04761-4 - Functional and structural characterization and immune response evaluation of a recombinant serine protease from Crotalus durissus collilineatus modified by PEGylation, BP.DD
16/11578-1 - Functional study of a disintegrin from Crotalus durissus collilineatus venom, BP.IC
+ associated scholarships 15/24701-3 - Studies of effects of a snake venom Phospholipase A2 on cells from the adipose tissue: adipogenesis and inflammatory response, BP.PD
16/04079-9 - Anti-inflammatory potential evaluation of crotoxin, a phospholipase A2 isolated from the venom of Crotalus durissus terrificus, in endotoxemia model, BP.IC
15/26901-0 - Immunomodulatory action and epigenetic and transcriptional evaluation of natural killer cells submitted to Bothrops moojeni L-amino acid oxidase enzyme and to Bothrops jararacussu BthTX-I phospholipase, BP.PD
15/26609-7 - Bothrops moojeni snake venomics: application of toxins of biotechnological interest obtained by omics techniques, BP.PD
15/25637-7 - Epigenetic modulation of apoptotic machinery in Bcr-Abl positive cells by BmooLAAO-I and MjTX-I toxins, BP.PD
15/24808-2 - Neuroprotective potential evaluation of a synthetic peptide in neurodegenerative diseases: evaluation of genotoxicity and mutagenicity, BP.PD
15/24010-0 - Structural and biophysical characterization of animal toxins, BP.PD
15/06290-6 - Evaluation of anti-inflammatory potential of crotoxin, a phospholipase A2 isolated from Crotalus durissus terrificus venom, in a disseminated intravascular coagulation model induced by endotoxemia, BP.PD
15/00740-0 - Therapeutic potential evaluation of L-amino acid oxidases isolated from snake venoms as antitumor: genotoxicity and gene expression studies, BP.PD
15/00847-9 - Evaluation of genotoxic potential of an isolated L-amino acid oxidase from Calloselasma rhodostoma (CR-LAAO) venom on human cell lines, BP.IC
14/19127-3 - Effect of Calloselasma rhodostoma and Bothrops moojeni LAAO on apoptotic machinery of JAK2V617F positive strains of myeloproliferative neoplasms, BP.IC
14/06170-8 - Biochemical and in vitro evaluation of fibroblast activation and leishmanicidal potential of an L-amino acid oxidase (LAAO) from Crotalus durissus terrificus venom, BP.MS
14/16182-3 - New functional perspectives of a serine protease from Crotalus durissus collilineatus: activity on voltage-gated ion channels, BP.PD
14/13717-3 - Immunomodulatory potential evaluation of Calloselasma rhodostoma raw venom and L-amino acid oxidase on the complement system, BP.IC
14/11266-4 - Structural and biophysical characterization of animal toxins, BP.PD
12/11963-1 - Effects of a metalloprotease and an acidic Phospholipase A2 from Bothrops atrox snake venom on the complement system and the inflammatory process, BP.PD
12/21569-9 - Antithrombotic and TROMBOLYTIC activities of BATROXASE, a metalloproteinase purified from the venom of Bothrops atrox snake, in experimental animal models, BP.PD - associated scholarships

Abstract

Animal venoms constitute a rich source of pharmacologically active substances. Such molecules, named toxins, act either isolated or in synergy through the binding to cell receptors and/or interfering metabolic pathways fundamental to cell viability, inducing local, systemic and even lethal damage to the victim or pray. Exploring the mechanisms of action of toxins has been relevant for providing the molecular basis of their toxicity, as well as by allowing the application of toxins in the development of new therapeutic strategies. In addition, animal toxins represent valuable tools for the elucidation of different metabolic pathways within the biological system. The present proposal aims to contribute to the mapping of new components of different snake venoms by the application of modern approaches for structural and functional characterization, and the study of plasma inhibitors of these animals. Investigating venoms from different snakes our studies will focus the characterization of molecules (proteins and peptides) that present activities on haemostasis, apoptosis, genomic stability and inflammatory processes; as well as involvement on neuroprotective, immunomodulatory, antiparasitic and antitumor effects. The application of very well established biological assays, associated to a complete characterization by the application of molecular biology, biochemical and biophysical tools, will be employed in studies of structure-function relationship, aiming not only to elucidate the toxicity mechanism, but also to explore the therapeutic potential of venom components in the development and production of new drugs. (AU)

Scientific publications (61)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE ANDRADE, CAMILA M.; REY, FERNANDA M.; CINTRA, ADELIA CRISTINA O.; SAMPAIO, SUELY V.; TORQUETI, MARIA REGINA. Effects of crotoxin, a neurotoxin from Crotalus durissus terrificus snake venom, on human endothelial cells. International Journal of Biological Macromolecules, v. 134, p. 613-621, AUG 1 2019. Web of Science Citations: 0.
DE ANDRADE, CAMILA M.; REY, FERNANDA M.; BIANCHINI, FRANCINE J.; SAMPAIO, SUELY V.; TORQUETI, MARIA REGINA. Crotoxin, a neurotoxin from Crotalus durissus terrificus snake venom, as a potential tool against thrombosis development. International Journal of Biological Macromolecules, v. 134, p. 653-659, AUG 1 2019. Web of Science Citations: 0.
WIEZEL, GISELE A.; RUSTIGUEL, JOANE K.; MORGENSTERN, DAVID; ZOCCAL, KARINA E.; FACCIOLI, LUCIA H.; CRISTINA NONATO, M.; UEBERHEIDE, BEATRIX; ARANTES, ELIANE C. Insights into the structure, function and stability of bordonein-L, the first L-amino acid oxidase from Crotalus durissus terrificus snake venom. Biochimie, v. 163, p. 33-49, AUG 2019. Web of Science Citations: 0.
ALVES BEZERRA, PATRICIA HELOISE; FERREIRA, ISADORA MARQUES; FRANCESCHI, BEATRIZ TINOCO; BIANCHINI, FRANCINE; AMBROSIO, LUCIANA; CINTRA, ADELIA CRISTINA O.; SAMPAIO, SUELY VILELA; DE CASTRO, FABIOLA ATTIE; TORQUETI, MARIA REGINA. BthTX-I from Bothrops jararacussu induces apoptosis in human breast cancer cell lines and decreases cancer stem cell subpopulation. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 25, JUL 29 2019. Web of Science Citations: 0.
AMORIM, FERNANDA GOBBI; LONGHIM, HELOISA TAVONI; COLOGNA, CAMILA TAKENO; DEGUELDRE, MICHEL; DE PAUW, EDWIN; QUINTON, LOIC; ARANTES, ELIANE CANDIANI. Proteome of fraction from Tityus serrulatus venom reveals new enzymes and toxins. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 25, APR 18 2019. Web of Science Citations: 0.
BALDO, MATEUS AMARAL; SIQUEIRA CUNHA, ALEXANDRA OLIMPIO; GODOY, LIVEA DORNELA; LIBERATO, JOSE LUIZ; YONEDA, JULIANA SAKAMOTO; FORNARI-BALDO, ELISA CORREA; CIANCAGLINI, PIETRO; DOS SANTOS, WAGNER FERREIRA; ARANTES, ELIANE CANDIANI. Assessment of neuropharmacological potential of low molecular weight components extracted from Rhinella schneideri toad poison. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 25, APR 18 2019. Web of Science Citations: 0.
MACHADO, A. R. T.; AISSA, A. F.; RIBEIRO, D. L.; COSTA, T. R.; FERREIRA, JR., R. S.; SAMPAIO, S. V.; ANTUNES, L. M. G. Cytotoxic, genotoxic, and oxidative stress-inducing effect of an L-amino acid oxidase isolated from Bothrops jararacussu venom in a co-culture model of HepG2 and HUVEC cells. International Journal of Biological Macromolecules, v. 127, p. 425-432, APR 15 2019. Web of Science Citations: 0.
WIEZEL, GISELE A.; BORDON, KARLA C. F.; SILVA, RONIVALDO R.; GOMES, MARIO S. R.; CABRAL, HAMILTON; RODRIGUES, VERIDIANA M.; UEBERHEIDE, BEATRIX; ARANTES, ELIANE C. Subproteome of Lachesis muta rhombeata venom and preliminary studies on LmrSP-4, a novel snake venom serine proteinase. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 25, APR 15 2019. Web of Science Citations: 0.
THOMAZELA MACHADO, ANA RITA; AISSA, ALEXANDRE FERRO; RIBEIRO, DIEGO LUIS; FERREIRA, JR., RUI SEABRA; SAMPAIO, SUELY VILELA; GREGGI ANTUNES, LUSANIA MARIA. BjussuLAAO-II induces cytotoxicity and alters DNA methylation of cell-cycle genes in monocultured/co-cultured HepG2 cells. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 25, MAR 11 2019. Web of Science Citations: 0.
DE OLIVEIRA, ISADORA SOUSA; CARDOSO, IARA AIME; FIGUEIREDO BORDON, KARLA DE CASTRO; IMAI CARONE, SANTE EMMANUEL; BOLDRINI-FRANCA, JOHARA; PUCCA, MANUELA BERTO; ZOCCAL, KARMA FURLANI; FACCIOLI, LUCIA HELENA; SAMPAIO, SUELY VILELA; ROSA, JOSE CESAR; ARANTES, ELIANE CANDIANI. Global proteomic and functional analysis of Crotalus durissus collilineatus individual venom variation and its impact on envenoming. JOURNAL OF PROTEOMICS, v. 191, n. SI, p. 153-165, JAN 16 2019. Web of Science Citations: 4.
BENATI, ROGERIO BODINI; COSTA, TASSIA RAFAELA; CACEMIRO, MAIRA DA COSTA; SAMPAIO, SUELY VILELA; DE CASTRO, FABIOLA ATTIE; BURIN, SANDRA MARA. Cytotoxic and pro-apoptotic action of MjTX-I, a phospholipase A2 isolated from Bothrops moojeni snake venom, towards leukemic cells. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, DEC 20 2018. Web of Science Citations: 1.
SARTIM, MARCO AURELIO; MENALDO, DANILO LUCCAS; SAMPAIO, SUELY VILELA. Immunotherapeutic potential of Crotoxin: anti-inflammatory and immunosuppressive properties. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, DEC 17 2018. Web of Science Citations: 0.
COSTA, TASSIA R.; CARONE, SANTE E. I.; TUCCI, LUIZ F. F.; MENALDO, DANILO L.; ROSA-GARZON, NATHALIA G.; CABRAL, HAMILTON; SAMPAIO, SUELY V. Kinetic investigations and stability studies of two Bothrops L-amino acid oxidases. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, DEC 4 2018. Web of Science Citations: 1.
AMORIM, FERNANDA G.; MENALDO, DANILO L.; CARONE, SANTE E. I.; SILVA, THIAGO A.; SARTIM, MARCO A.; DE PAUW, EDWIN; QUINTON, LOIC; SAMPAIO, SUELY V. New Insights on Moojase, a Thrombin-Like Serine Protease from Bothrops moojeni Snake Venom. TOXINS, v. 10, n. 12 DEC 2018. Web of Science Citations: 0.
DE OLIVEIRA, ISADORA SOUSA; PUCCA, MANUELA BERTO; SAMPAIO, SUELY VILELA; ARANTES, ELIANE CANDIANI. Antivenomic approach of different Crotalus durissus collilineatus venoms. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, NOV 26 2018. Web of Science Citations: 0.
CEDRO, RAFHAELLA C. A.; MENALDO, DANILO L.; COSTA, TASSIA R.; ZOCCAL, KARINA F.; SARTIM, MARCO A.; SANTOS-FILHO, NORIVAL A.; FACCIOLI, LUCIA H.; SAMPAIO, SUELY V. Cytotoxic and inflammatory potential of a phospholipase A(2) from Bothrops jararaca snake venom. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, NOV 23 2018. Web of Science Citations: 1.
CORDEIRO, FRANCIELLE ALMEIDA; COUTINHO, BARBARA MARQUES; WIEZEL, GISELE ADRIANO; FIGUEIREDO BORDON, KARLA DE CASTRO; BREGGE-SILVA, CRISTIANE; ROSA-GARZON, NATHALIA GONSALES; CABRAL, HAMILTON; UEBERHEIDE, BEATRIX; ARANTES, ELIANE CANDIANI. Purification and enzymatic characterization of a novel metalloprotease from Lachesis muta rhombeata snake venom. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, NOV 22 2018. Web of Science Citations: 0.
WIEZEL, GISELE A.; SHIBAO, PRISCILA Y. T.; COLOGNA, CAMILA T.; MORANDI FILHO, ROMUALDO; UEIRA-VIEIRA, CARLOS; DE PAUW, EDWIN; QUINTON, LOIC; ARANTES, ELIANE C. In-Depth Venome of the Brazilian Rattlesnake Crotalus durissus terrificus: An Integrative Approach Combining Its Venom Gland Transcriptome and Venom Proteome. JOURNAL OF PROTEOME RESEARCH, v. 17, n. 11, p. 3941-3958, NOV 2018. Web of Science Citations: 1.
DE OLIVEIRA, ISADORA SOUSA; MANZINI, RAFAELLA VARZONI; FERREIRA, ISABELA GOBBO; CARDOSO, IARA AIME; FIGUEIREDO BORDON, KARLA DE CASTRO; THOMAZELA MACHADO, ANA RITA; GREGGI ANTUNES, LUSANIA MARIA; ROSA, JOSE CESAR; ARANTES, ELIANE CANDIANI. Cell migration inhibition activity of a non-RGD disintegrin from Crotalus durissus collilineatus venom. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, OCT 20 2018. Web of Science Citations: 0.
CARONE, I, SANTE E.; MENALDO, DANILO L.; SARTIM, MARCO A.; BERNARDES, CAROLINA P.; CAETANO, RENATO C.; DA SILVA, RONIVALDO R.; CABRAL, HAMILTON; BARRAVIERA, BENEDITO; FERREIRA JUNIOR, RUI S.; SAMPAIO, V, SUELY. BjSP, a novel serine protease from Bothrops jararaca snake venom that degrades fibrinogen without forming fibrin clots. Toxicology and Applied Pharmacology, v. 357, p. 50-61, OCT 15 2018. Web of Science Citations: 1.
COSTA, TASSIA R.; AMSTALDEN, MARTIN K.; RIBEIRO, DIEGO L.; MENALDO, DANILO L.; SARTIM, MARCO A.; AISSA, ALEXANDRE F.; ANTUNES, LUSANIA M. G.; SAMPAIO, V, SUELY. CR-LAAO causes genotoxic damage in HepG2 tumor cells by oxidative stress. Toxicology, v. 404, p. 42-48, JUL 1 2018. Web of Science Citations: 2.
BERNARDES, CAROLINA P.; SANTOS, NEIFE A. G.; SISTI, FLAVIA M.; FERREIRA, RAFAELA SCALCO; SANTOS-FILHO, NORIVAL A.; CINTRA, ADELIA C. O.; CILLI, EDUARDO M.; SAMPAIO, V, SUELY; SANTOS, ANTONIO C. A synthetic snake-venom-based tripeptide (Glu-Val-Trp) protects PC12 cells from MPP+ toxicity by activating the NGF-signaling pathway. Peptides, v. 104, p. 24-34, JUN 2018. Web of Science Citations: 1.
AMORIM, FERNANDA GOBBI; COSTA, TASSIA RAFAELA; BAIWIR, DOMINIQUE; DE PAUW, EDWIN; QUINTON, LOIC; SAMPAIO, SUELY VILELA. Proteopeptidomic, Functional and Immunoreactivity Characterization of Bothrops moojeni Snake Venom: Influence of Snake Gender on Venom Composition. TOXINS, v. 10, n. 5 MAY 2018. Web of Science Citations: 5.
BURIN, SANDRA M.; MENALDO, DANILO L.; SAMPAIO, SUELY V.; FRANTZ, FABIANI G.; CASTRO, FABIOLA A. An overview of the immune modulating effects of enzymatic toxins from snake venoms. International Journal of Biological Macromolecules, v. 109, p. 664-671, APR 2018. Web of Science Citations: 1.
MACHADO, A. R. T.; AISSA, A. F.; RIBEIRO, D. L.; HERNANDES, L. C.; MACHADO, C. S.; BIANCHI, M. L. P.; SAMPAIO, S. V.; ANTUNES, L. M. G. The toxin BjussuLAAO-II induces oxidative stress and DNA damage, upregulates the inflammatory cytokine genes TNF and IL6, and downregulates the apoptotic-related genes BAX, BCL2 and RELA in human Caco-2 cells. International Journal of Biological Macromolecules, v. 109, p. 212-219, APR 2018. Web of Science Citations: 7.
RAFHAELLA C. A. CEDRO; DANILO L. MENALDO; TÁSSIA R. COSTA; KARINA F. ZOCCAL; MARCO A. SARTIM; NORIVAL A. SANTOS-FILHO; LÚCIA H. FACCIOLI; SUELY V. SAMPAIO. Cytotoxic and inflammatory potential of a phospholipase A2 from Bothrops jararaca snake venom. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, p. -, 2018.
AMORIM, FERNANDA GOBBI; MORANDI-FILHO, ROMUALDO; FUJIMURA, PATRICIA TIEME; UEIRA-VIEIRA, CARLOS; SAMPAIO, SUELY VILELA. New findings from the first transcriptome of the Bothrops moojeni snake venom gland. Toxicon, v. 140, p. 105-117, DEC 15 2017. Web of Science Citations: 6.
CARONE, SANTE E. I.; COSTA, TASSIA R.; BURIN, SANDRA M.; CINTRA, ADELIA C. O.; ZOCCAL, KARINA F.; BIANCHINI, FRANCINE J.; TUCCI, LUIZ F. F.; FRANCO, JOAO J.; TORQUETI, MARIA R.; FACCIOLI, LUCIA H.; DE ALBUQUERQUE, SERGIO; DE CASTRO, FABIOLA A.; SAMPAIO, SUELY V. A new L-amino acid oxidase from Bothrops jararacussu snake venom: Isolation, partial characterization, and assessment of pro-apoptotic and antiprotozoal activities. International Journal of Biological Macromolecules, v. 103, p. 25-35, OCT 2017. Web of Science Citations: 13.
SARTIM, MARCO A.; CEZARETTE, GABRIEL N.; JACOB-FERREIRA, ANNA L.; FRANTZ, FABIANI G.; FACCIOLI, LUCIA H.; SAMPAIO, SUELY V. Disseminated intravascular coagulation caused by moojenactivase, a procoagulant snake venom metalloprotease. International Journal of Biological Macromolecules, v. 103, p. 1077-1086, OCT 2017. Web of Science Citations: 3.
MENALDO, DANILO L.; BERNARDES, CAROLINA P.; ZOCCAL, KARINA F.; JACOB-FERREIRA, ANNA L.; COSTA, TASSIA R.; DEL LAMA, MARIA P. F. M.; NAAL, ROSE M. Z. G.; FRANTZ, FABIANI G.; FACCIOLI, LUCIA H.; SAMPAIO, SUELY V. Immune cells and mediators involved in the inflammatory responses induced by a P-I metalloprotease and a phospholipase A(2) from Bothrops atrox venom. Molecular Immunology, v. 85, p. 238-247, MAY 2017. Web of Science Citations: 7.
PALACIO, TATIANA Z.; SANTOS-FILHO, NORIVAL A.; ROSA, JOSE CESAR; FERREIRA JUNIOR, RUI S.; BARRAVIERA, BENEDITO; SAMPAIO, SUELY V. Isolation and characterization of a novel metalloprotease inhibitor from Bothrops alternatus snake serum. International Journal of Biological Macromolecules, v. 98, p. 436-446, MAY 2017. Web of Science Citations: 3.
BOLDRINI-FRANCA, JOHARA; COLOGNA, CAMILA TAKENO; PUCCA, MANUELA BERTO; FIGUEIREDO BORDON, KARLA DE CASTRO; AMORIM, FERNANDO GOBBI; PINO ANJOLETTE, FERNANDO ANTONIO; CORDEIRO, FRANCIELLE ALMEIDA; WIEZEL, GISELE ADRIANO; CERNI, FELIPE AUGUSTO; PINHEIRO-JUNIOR, ERNESTO LOPES; TANAKA SHIBAO, PRISCILA YUMI; FERREIRA, ISABELA GOBBO; DE OLIVEIRA, ISADORA SOUSA; CARDOSO, LARA AIME; ARANTES, ELIANE CANDIANI. Minor snake venom proteins: Structure, function and potential applications. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1861, n. 4, p. 824-838, APR 2017. Web of Science Citations: 15.
COSTA, TASSIA R.; MENALDO, DANILO L.; ZOCCAL, KARINA F.; BURIN, SANDRA M.; AISSA, ALEXANDRE F.; DE CASTRO, FABIOLA A.; FACCIOLI, LUCIA H.; GREGGI ANTUNES, LUSANIA M.; SAMPAIO, SUELY V. CR-LAAO, an L-amino acid oxidase from Calloselasma rhodostoma venom, as a potential tool for developing novel immunotherapeutic strategies against cancer. SCIENTIFIC REPORTS, v. 7, FEB 16 2017. Web of Science Citations: 17.
JACOB-FERREIRA, ANNA L.; MENALDO, DANILO L.; SARTIM, MARCO A.; RIUL, THALITA B.; DIAS-BARUFFI, MARCELO; SAMPAIO, SUELY V. Antithrombotic activity of Batroxase, a metalloprotease from Bothrops atrox venom, in a model of venous thrombosis. International Journal of Biological Macromolecules, v. 95, p. 263-267, FEB 2017. Web of Science Citations: 6.
SARTIM, MARCO A.; PINHEIRO, MATHEUS P.; DE PADUA, RICARDO A. P.; SAMPAIO, SUELY V.; CRISTINA NONATO, M. Structural and binding studies of a C-type galactose-binding lectin from Bothrops jararacussu snake venom. Toxicon, v. 126, p. 59-69, FEB 2017. Web of Science Citations: 5.
LODOVICHO, MARINA E.; COSTA, TASSIA R.; BERNARDES, CAROLINA P.; MENALDO, DANILO L.; ZOCCAL, KARINA F.; CARONE, SANTE E.; ROSA, JOSE C.; PUCCA, MANUELA B.; CERNI, FELIPE A.; ARANTES, ELIANE C.; TYTGAT, JAN; FACCIOLI, LUCIA H.; PEREIRA-CROTT, LUCIANA S.; SAMPAIO, SUELY V. Investigating possible biological targets of Bj-CRP, the first cysteine-rich secretory protein (CRISP) isolated from Bothrops jararaca snake venom. Toxicology Letters, v. 265, p. 156-169, JAN 4 2017. Web of Science Citations: 9.
SANTOS-FILHO, NORIVAL A.; SOUSA, TIAGO S.; BOLDRINI-FRANCA, JOHARA; SANTOS-SILVA, LUDIER K.; MENALDO, DANILO L.; HENRIQUE-SILVA, FLAVIO; CINTRA, ADELIA C. O.; LAURE, HELEN J.; MAMEDE, CARLA C. N.; OLIVEIRA, FABIO; RIUL, THALITA B.; DIAS-BARUFFI, MARCELO; ROSA, JOSE C.; SAMPAIO, SUELY V. rBaltMIP, a recombinant alpha-type myotoxin inhibitor from Bothrops alternatus (Rhinocerophis alternatus) snake, as a potential candidate to complement the antivenom therapy. Toxicon, v. 124, p. 53-62, DEC 15 2016. Web of Science Citations: 1.
MENALDO, DANILO L.; BERNARDES, CAROLINA P.; JACOB-FERREIRA, ANNA L.; NOGUEIRA-SANTOS, CINTIA G.; CASARE-OGASAWARA, TANIA M.; PEREIRA-CROTT, LUCIANA S.; SAMPAIO, SUELY V. Effects of Bothrops atrox venom and two isolated toxins on the human complement system: Modulation of pathways and generation of anaphylatoxins. Molecular Immunology, v. 80, p. 91-100, DEC 2016. Web of Science Citations: 5.
BURIN, SANDRA MARA; BERZOTI-COELHO, MARIA GABRIELA; COMINAL, JUCARA GASTALDI; AMBROSIO, LUCIANA; TORQUETI, MARIA REGINA; SAMPAIO, SUELY VILELA; DE CASTRO, FABIOLA ATTIE. The L-amino acid oxidase from Calloselasma rhodostoma snake venom modulates apoptomiRs expression in Bcr-Abl-positive cell lines. Toxicon, v. 120, p. 9-14, SEP 15 2016. Web of Science Citations: 10.
CRISTIANE TAVARES; THAÍS MACIEL; SANDRA BURIN; LUCIANA AMBRÓSIO; SANDRO GHISLA; SUELY SAMPAIO; FABÍOLA CASTRO. l-Amino acid oxidase isolated from Calloselasma rhodostoma snake venom induces cytotoxicity and apoptosis in JAK2V617F-positive cell lines. Revista Brasileira de Hematologia e Hemoterapia, v. 38, n. 2, p. 128-134, Jun. 2016.
BURIN, SANDRA MARA; GHISLA, SANDRO; OUCHIDA, AMANDA TOMIE; AISSA, ALEXANDRE FERRO; BERZOTI COELHO, MARIA GABRIELA; COSTA, TASSIA RAFAELLA; ZAMBUZI CARDOSO MARSOLA, ANA PAULA; PINTO-SIMOES, BELINDA; GREGGI ANTUNES, LUSANIA MARIA; CURTI, CARLOS; SAMPAIO, SUELY VILELA; DE CASTRO, FABIOLA ATTIE. CR-LAAO antileukemic effect against Bcr-Abl(+) cells is mediated by apoptosis and hydrogen peroxide. International Journal of Biological Macromolecules, v. 86, p. 309-320, MAY 2016. Web of Science Citations: 16.
SARTIM, MARCO A.; COSTA, TASSIA R.; LAURE, HELEN J.; ESPINDOLA, MILENA S.; FRANTZ, FABIANI G.; SORGI, CARLOS A.; CINTRA, ADELIA C. O.; ARANTES, ELIANE C.; FACCIOLI, LUCIA H.; ROSA, JOSE C.; SAMPAIO, SUELY V. Moojenactivase, a novel pro-coagulant PIIId metalloprotease isolated from Bothrops moojeni snake venom, activates coagulation factors II and X and induces tissue factor up-regulation in leukocytes. ARCHIVES OF TOXICOLOGY, v. 90, n. 5, p. 1261-1278, MAY 2016. Web of Science Citations: 9.
JACOB-FERREIRA, ANNA L.; MENALDO, DANILO L.; BERNARDES, CAROLINA P.; SARTIM, MARCO A.; DE ANGELIS, CELIO D.; TANUS-SANTOS, JOSE E.; SAMPAIO, SUELY V. Evaluation of the in vivo thrombolytic activity of a metalloprotease from Bothrops atrox venom using a model of venous thrombosis. Toxicon, v. 109, p. 18-25, JAN 2016. Web of Science Citations: 9.
ANDREIA VIEIRA PEREIRA; GUSTAVO DE BARROS; ERIKA GRACIELLE PINTO; ANDRE GUSTAVO TEMPONE; RICARDO DE OLIVEIRA ORSI; LUCILENE DELAZARI DOS SANTOS; SUELI CALVI; RUI SEABRA FERREIRA JR; DANIEL CARVALHO PIMENTA; BENEDITO BARRAVIERA. Melittin induces in vitro death of Leishmania (Leishmania) infantum by triggering the cellular innate immune response. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 22, 2016.
BISCOLA, NATALIA PERUSSI; CARTAROZZI, LUCIANA POLITTI; FERREIRA JUNIOR, RUI SEABRA; BARRAVIERA, BENEDITO; RODRIGUES DE OLIVEIRA, ALEXANDRE LEITE. Long-Standing Motor and Sensory Recovery following Acute Fibrin Sealant Based Neonatal Sciatic Nerve Repair. NEURAL PLASTICITY, 2016. Web of Science Citations: 8.
WIEZEL, GISELE A.; DOS SANTOS, PATTY K.; CORDEIRO, FRANCIELLE A.; BORDON, KARLA C. F.; SELISTRE-DE-ARAUJO, HELOISA S.; UEBERHEIDE, BEATRIX; ARANTES, ELIANE C. Identification of hyaluronidase and phospholipase B in Lachesis muta rhombeata venom. Toxicon, v. 107, n. B, SI, p. 359-368, DEC 1 2015. Web of Science Citations: 11.
CASELLA-MARTINS, ANDREA; AYRES, LORENA R.; BURIN, SANDRA M.; MORAIS, FABIANA R.; PEREIRA, JULIANA C.; FACCIOLI, LUCIA H.; SAMPAIO, SUELY V.; ARANTES, ELIANE C.; CASTRO, FABIOLA A.; PEREIRA-CROTT, LUCIANA S. Immunomodulatory activity of Tityus serrulatus scorpion venom on human T lymphocytes. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 21, NOV 11 2015. Web of Science Citations: 8.
DA SILVA, CASSIO PRINHOLATO; COSTA, TASSIA R.; PAIVA, RAQUEL M. ALVES; CINTRA, ADELIA C. O.; MENALDO, DANILO L.; ANTUNES, LUSANIA M. GREGGI; SAMPAIO, SUELY V. Antitumor potential of the myotoxin BthTX-I from Bothrops jararacussu snake venom: evaluation of cell cycle alterations and death mechanisms induced in tumor cell lines. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 21, NOV 3 2015. Web of Science Citations: 14.
BORDON, KARLA C. F.; WIEZEL, GISELE A.; AMORIM, FERNANDA G.; ARANTES, ELIANE C. Arthropod venom Hyaluronidases: biochemical properties and potential applications in medicine and biotechnology. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 21, OCT 22 2015. Web of Science Citations: 25.
SARTIM, MARCO A.; SAMPAIO, SUELY V. Snake venom galactoside-binding lectins: a structural and functional overview. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 21, SEP 24 2015. Web of Science Citations: 13.
COSTA, TASSIA R.; MENALDO, DANILO L.; DA SILVA, CASSIO PRINHOLATO; SORRECHIA, RODRIGO; DE ALBUQUERQUE, SERGIO; PIETRO, ROSEMEIRE C. L. R.; GHISLA, SANDRO; ANTUNES, LUSANIA M. GREGGI; SAMPAIO, SUELY V. Evaluating the microbicidal, antiparasitic and antitumor effects of CR-LAAO from Calloselasma rhodostoma venom. International Journal of Biological Macromolecules, v. 80, p. 489-497, SEP 2015. Web of Science Citations: 23.
AYRES, LORENA ROCHA; RECIO, ALEX DOS REIS; BURIN, SANDRA MARA; PEREIRA, JULIANA CAMPOS; MARTINS, ANDREA CASELLA; SAMPAIO, SUELY VILELA; DE CASTRO, FABIOLA ATTIE; PEREIRA-CROTT, LUCIANA SIMON. Bothrops snake venoms and their isolated toxins, an L-amino acid oxidase and a serine protease, modulate human complement system pathways. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 21, AUG 13 2015. Web of Science Citations: 12.
BORDON, KARLA C. F.; WIEZEL, GISELE A.; CABRAL, HAMILTON; ARANTES, ELIANE C. Bordonein-L, a new L-amino acid oxidase from Crotalus durissus terrificus snake venom: isolation, preliminary characterization and enzyme stability. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 21, AUG 13 2015. Web of Science Citations: 14.
MENALDO, DANILO L.; JACOB-FERREIRA, ANNA L.; BERNARDES, CAROLINA P.; CINTRA, ADELIA C. O.; SAMPAIO, SUELY V. Purification procedure for the isolation of a P-I metalloprotease and an acidic phospholipase A(2) from Bothrops atrox snake venom. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 21, AUG 13 2015. Web of Science Citations: 8.
CARTAROZZI, LUCIANA P.; SPEJO, ALINE B.; FERREIRA, JR., RUI S.; BARRAVIERA, BENEDITO; DUEK, ELIANA; CARVALHO, JULIANA L.; GOES, ALFREDO M.; OLIVEIRA, ALEXANDRE L. R. Mesenchymal stem cells engrafted in a fibrin scaffold stimulate Schwann cell reactivity and axonal regeneration following sciatic nerve tubulization. Brain Research Bulletin, v. 112, p. 14-24, MAR 2015. Web of Science Citations: 22.
BERNARDES, CAROLINA P.; MENALDO, DANILO L.; MAMEDE, CARLA C. N.; ZOCCAL, KARINA F.; CINTRA, ADELIA C. O.; FACCIOLI, LUCIA H.; STANZIOLA, LEONILDA; DE OLIVEIRA, FABIO; SAMPAIO, SUELY V. Evaluation of the local inflammatory events induced by BpirMP, a metalloproteinase from Bothrops pirajai venom. Molecular Immunology, v. 68, n. 2, B, p. 456-464, 2015. Web of Science Citations: 11.
DA-SILVA-FREITAS, DEBORA; BOLDRINI-FRANCA, JOHARA; ARANTES, ELIANE CANDIANI. PEGylation: A Successful Approach to Improve the Biopharmaceutical Potential of Snake Venom Thrombin-Like Serine Protease. PROTEIN AND PEPTIDE LETTERS, v. 22, n. 12, p. 1133-1139, 2015. Web of Science Citations: 3.
DANILO L. MENALDO; ANNA L. JACOB-FERREIRA; CAROLINA P. BERNARDES; ADÉLIA C. O. CINTRA; SUELY V. SAMPAIO. Purification procedure for the isolation of a P-I metalloprotease and an acidic phospholipase A 2 fromBothrops atrox snake venom. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 21, p. 0-0, 2015.
BARBIZAN, ROBERTA; CASTRO, MATEUS V.; FERREIRA, JR., RUI SEABRA; BARRAVIERA, BENEDITO; OLIVEIRA, ALEXANDRE L. R. Long-Term Spinal Ventral Root Reimplantation, but not Bone Marrow Mononuclear Cell Treatment, Positively Influences Ultrastructural Synapse Recovery and Motor Axonal Regrowth. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 15, n. 11, p. 19535-19551, NOV 2014. Web of Science Citations: 10.
SANTOS-FILHO, NORIVAL A.; BOLDRINI-FRANCA, JOHARA; SANTOS-SILVA, LUDIER K.; MENALDO, DANILO L.; HENRIQUE-SILVA, FLAVIO; SOUSA, TIAGO S.; CINTRA, ADELIA C. O.; MAMEDE, CARLA C. N.; OLIVEIRA, FABIO; ARANTES, ELIANE C.; GREGGI ANTUNES, LUSANIA M.; CILLI, EDUARDO M.; SAMPAIO, SUELY V. Heterologous expression and biochemical and functional characterization of a recombinant alpha-type myotoxin inhibitor from Bothrops alternatus snake. Biochimie, v. 105, p. 119-128, OCT 2014. Web of Science Citations: 9.
COSTA, TASSIA R.; BURIN, SANDRA M.; MENALDO, DANILO L.; DE CASTRO, FABIOLA A.; SAMPAIO, SUELY V. Snake venom L-amino acid oxidases: an overview on their antitumor effects. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 20, JUN 2 2014. Web of Science Citations: 38.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.