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Studies of effects of a snake venom phospholipase A2 on cells from the adipose tissue: Adipogenesis and inflammatory response

Grant number: 15/24701-3
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): May 01, 2016
Effective date (End): April 30, 2019
Field of knowledge:Biological Sciences - Pharmacology
Principal Investigator:Catarina de Fatima Pereira Teixeira
Grantee:Elbio Leiguez Junior
Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Associated research grant:11/23236-4 - Native and recombinant animal toxins: functional, structural and molecular analysis, AP.TEM


Animal toxins play a singular role in the biomedical sciences. During the evolutionary process, animal toxins suffered a complexification of their chemical structures in response to specific targets of their prey. Thereby, the toxins purified from snake venoms have been used as critical scientific tools to studies of physiological and pathophysiological mechanisms and processes, among other purposes. Snake venoms from the Viperidae family contain high levels of lipolytic enzymes named phospholipases A2 (PLA2s). MT-III, a PLA2 isolated from Bothrops asper snake venom, presents potent inflammatory activity and activates different functions of immunecompetent cells. Moreover, MT-III presents structural and functional homology with mammalian group IIA PLA2s, found in high levels in patients with inflammatory disorders. Thus, MT-III constitutes a relevant scientific tool to understand the roles played by group IIA PLA2s in pathophysiological processes associated with inflammation. Obesity is a metabolic disorder associated to inflammation. The incidence of this disease has increased dramatically in recent decades, representing a risk factor for loss of health in contemporary society. Group IIA PLA2s, are found in high levels in the serum of obese patients and in inflamed adipose tissue, suggesting an important role for this group of enzymes in initiation and/or development of obesity. However, the effects of Group IIA PLA2s in adipose tissue are still unknown. Thus, this study aims to investigate the effects and mechanisms triggered by MT-III in cells isolated from adipose tissue, such as mesenchymal stem cells and adipocytes, with focus on cell differentiation, adipogênese and activation of the inflammatory process, aiming a better understanding of the cellular and molecular mechanisms involved in obesity. In addition, considering that obesity is a risk factor for the development of many chronic diseases, such as diabetes and cardiovascular disease, this study may highlight new therapeutic targets and development of new strategies for the prevention and/or treatment of obesity and associated diseases.

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LEIGUEZ, ELBIO; MOTTA, PRISCILA; MAIA MARQUES, RODRIGO; LOMONTE, BRUNO; SAMPAIO, SUELY VILELA; TEIXEIRA, CATARINA. A Representative GIIA Phospholipase A(2) Activates Preadipocytes to Produce Inflammatory Mediators Implicated in Obesity Development. BIOMOLECULES, v. 10, n. 12, . (11/23236-4, 15/24701-3)
TEIXEIRA, CATARINA; FERNANDES, CRISTINA MARIA; LEIGUEZ, ELBIO; CHUDZINSKI-TAVASSI, ANA MARISA. Inflammation Induced by Platelet-Activating Viperid Snake Venoms: Perspectives on Thromboinflammation. FRONTIERS IN IMMUNOLOGY, v. 10, . (15/24701-3, 15/50040-4)
GIANNOTTI, KARINA CRISTINA; WEINERT, SOENKE; VIANA, MARIANA NASCIMENTO; LEIGUEZ, ELBIO; ARAUJO, THAIS L. S.; LAURINDO, FRANCISCO R. M.; LOMONTE, BRUNO; BRAUN-DULLAEUS, RUEDIGER; TEIXEIRA, CATARINA. A Secreted Phospholipase A(2) Induces Formation of Smooth Muscle Foam Cells Which Transdifferentiate to Macrophage-Like State. Molecules, v. 24, n. 18, . (13/22610-5, 15/24701-3, 16/14046-0, 14/18549-1)
ZULIM DE CARVALHO, ANA EDUARDA; GIANNOTTI, KARINA; LEIGUEZ JUNIOR, ELBIO; MATSUBARA, MARCIO; DOS SANTOS, MARIA CRISTINA; FORTES-DIAS, CONSUELO LATORRE; TEIXEIRA, CATARINA. Crotalus durissus ruruima Snake Venom and a Phospholipase A(2) Isolated from This Venom Elicit Macrophages to Form Lipid Droplets and Synthesize Inflammatory Lipid Mediators. JOURNAL OF IMMUNOLOGY RESEARCH, v. 2019, . (15/24701-3, 14/18549-1, 18/05637-0, 15/50040-4)
LEIGUEZ, ELBIO; GIANNOTTI, KARMA CRISTINA; VIANA, MARIANA DO NASCIMENTO; MATSUBARA, MARCIO HIDEKI; FERNANDES, CRISTINA MARIA; GUTIERREZ, JOSE MARIA; LOMONTE, BRUNO; TEIXEIRA, CATARINA. A Snake Venom-Secreted Phospholipase A(2) Induces Foam Cell Formation Depending on the Activation of Factors Involved in Lipid Homeostasis. Mediators of Inflammation, . (11/21341-5, 15/24701-3, 14/18549-1, 13/22610-5, 10/08506-2, 10/06345-1)

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