| Grant number: | 12/05298-5 |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| Start date: | June 01, 2012 |
| End date: | August 31, 2015 |
| Field of knowledge: | Biological Sciences - Physiology - Physiology of Organs and Systems |
| Principal Investigator: | Dora Selma Fix Ventura |
| Grantee: | Gabriela Lourençon Ioshimoto |
| Host Institution: | Instituto de Psicologia (IP). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| Associated research grant: | 08/58731-2 - Vision as a sensitive indicator of conditions threatening retinal and central nervous system function, AP.TEM |
Abstract Uveitis is a chronic intraocular inflammation of the uvea (iris, choroid and ciliary body) and an important cause of blindness worldwide. The autoimmune uveitis (or noninfectious) can be triggered by environmental, genetic or immunological stimuli. In most cases, the causal agent of inflammation is unknown or undetectable. Mycophenolate mofetil (MMF) is a potent immunosuppressive drug taken orally that has been used successfully in the treatment of uveitis, but whose side effects often require interruption of treatment. MMF is a pro-drug which is converted in the liver to mycophenolic acid (MPA), the active immunosuppressor. To maintain concentration and release the drug in the target organ and reduce systemic and intraocular toxicity we will test the effects of a MPA biodegradable intravitreal implant in rabbit eyes. The first phase of this work aims to establish a functional profile of primary safety, pharmacokinetic and morphological study of the intravitreal implant of MPA (400 ¼g) and the second phase will examine treatment evolution in rabbit models of autoimmune uveitis using morphological and electrophysiological techniques. | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
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