Study of application of X-ray scattering techniques to produce breast nanoimages

• Grant number: 11/20632-6
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• Start date: April 01, 2012
• End date: January 31, 2013
• Field of knowledge: Health Sciences - Medicine - Medical Radiology
• Principal Investigator: Martin Eduardo Poletti
• Grantee: André Luiz Coelho Conceição
• Supervisor: Sérgio de Souza Funari
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Institution abroad: Deutsches Elektronen-Synchrotron (DESY), Germany
• Associated to the scholarship: 10/20642-9 - Study of new modalities of imaging based on x-ray scattering properties for breast câncer diagnosis, BP.PD

Abstract

The increasing development of technologies for nanoscale study has provided advances in several areas, including medicine. In nanomedicine, the demand for less invasive methods for breast cancer diagnosis at early stage has attracted the interest of researchers since the early diagnosis of this disease greatly increases the chances of cure of the patients. In this sense, the purpose of this project is to study the combination of the computed tomography imaging method with techniques for X-ray scattering using the tools available to explore nanoscale at synchrotron light laboratories to produce three-dimensional images of normal and neoplastic human breast tissues with nanometer resolution. The images obtained will allow to inspect the entire breast volume in 3D with higher contrast between healthy and neoplastic tissue by using the technique of X-ray diffraction nanotomography computerized imaging (nTC-IXRD), and information about the spread of cancer in the supramolecular scale from small angle x-ray scattering nanotomography computerized imaging (nTC-ISAXS), a less invasive manner. This type of study is potentially important in healthcare because it is associated with the study of new radiological techniques that will complement the information of current imaging techniques and thus increase the capability of breast cancer diagonosis. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CONCEICAO, A. L. C.; PERLICH, J.; HAAS, S.; FUNARI, S. S.. SAXS-CT: a nanostructure resolving microscopy for macroscopic biologic specimens. BIOMEDICAL PHYSICS & ENGINEERING EXPRESS, v. 6, n. 3, MAR 2020. (11/20632-6)

CONCEICAO, A. L. C.; MEEHAN, K.; ANTONIASSI, M.; PIACENTI-SILVA, M.; POLETTI, M. E.. The influence of hydration on the architectural rearrangement of normal and neoplastic human breast tissues. HELIYON, v. 5, n. 2, FEB 2019. (11/20632-6)