| Grant number: | 11/23366-5 |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| Start date: | July 01, 2012 |
| End date: | June 30, 2015 |
| Field of knowledge: | Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology |
| Principal Investigator: | Albina Messias de Almeida Milani Altemani |
| Grantee: | Fernanda Viviane Mariano Brum Corrêa |
| Host Institution: | Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil |
Abstract Carcinoma ex pleomorphic adenoma (CXPA) is an aggressive neoplasm, and its pathogenesis is still unclear, although it is believed to result from the accumulation of genetic alterations in pleomorphic adenomas (PAs) with long duration. In this project we will study a group of CXPAs composed of tumors in different stages of carcinogenesis (intracapsular, minimally and frankly invasive), and classified according to histologic subtypes by array-comparative genomic hybridization (array-CGH). The literature review shows that this technique has been used to explore chromosomal changes only in a few cases of CXPA. Array-CGH will allow us a global analysis of changes in chromosome copy number in a representative sample, unlike the traditional cytogenetic techniques. Tumor cells have multiple gains and losses of whole chromosomes or arms, therefore, the array-CGH can potentially reveal copy number changes in chromosomal locus unexplored. The study of a group of CXPA in different stages of carcinogenesis with this technique will enable the identification of changes in copy number of chromosomal regions associated with tumor progression. The search for sites of genes involved in tumor progression may provide prognostic indicators of clinical disease. (AU) | |
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