| Grant number: | 12/13658-1 |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate (Direct) |
| Start date: | September 01, 2012 |
| End date: | February 28, 2013 |
| Field of knowledge: | Biological Sciences - Biochemistry - Molecular Biology |
| Principal Investigator: | Daniel Scherer de Moura |
| Grantee: | Keini Dressano |
| Supervisor: | Joanne Chory |
| Host Institution: | Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil |
| Institution abroad: | Salk Institute For Biological Studies, United States |
| Associated to the scholarship: | 11/17264-5 - RALF and the brassinosteroid receptor complex: interaction of peptide AtRALF1 and protein BAK1, a membrane protein receptor BRI1 associated kinase, BP.DD |
Abstract This project is part of a PhD scholarship from FAPESP that was implemented in July 2010 under the title "RALF and the brassinosteroid receptor complex: interaction of peptide AtRALF1 and protein BAK1, a membrane protein receptor BRI1 associated kinase”. RALF peptides are signaling molecules with hormonal characteristics and since their discovery, efforts have been done towards the identification of its receptor. Our study of the role of RALF in cell expansion (Mingossi et al., 2010) and the interaction of RALF with other hormones (Bergonci e Moura, FAPESP 2010/03497-5) led us to conclude that RALF and the brassinosteroid hormone brassinolide (BL) have antagonistic functions. As a consequence of these results, we evaluated a series of Arabidopsis mutants having a BL signaling pathway compromised. Surprisingly, the LRR-RK BRI1-Associated Kinase 1 (BAK1) showed no effect upon treatment with RALF. Several experiments already performed during the PhD program (details in the project) suggest that BAK1 protein is itself the AtRALF1 receptor, the RALF isoform 1 in Arabidopsis. We now seek, with the short stay abroad, a complementation of these results with the techniques, know-how and genetic material that is not available in our laboratory. The laboratory where we are planning to do the proposed experiments has experience and prestige attested by its high level of publications. Dr Joanne Chory’s group has published over a 160 original articles and more than 50 reviews. In the last 5 years, her group has published, among others, eight articles in Nature, 10 in PNAS and 4 in Cell. (AU) | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
| More itemsLess items | |
| TITULO | |
| Articles published in other media outlets ( ): | |
| More itemsLess items | |
| VEICULO: TITULO (DATA) | |
| VEICULO: TITULO (DATA) | |