SEMAPHORINS AND NEUROPILINS IN SALIVARY GLAND TUMORS

• Grant number: 12/07519-9
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): July 01, 2012
• Effective date (End): February 28, 2015
• Field of knowledge: Health Sciences - Dentistry
• Principal Investigator: Pablo Agustin Vargas
• Grantee: Felipe Paiva Fonseca
• Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil

Abstract

Salivary gland tumors is a highly heterogeneous group that accounts for 3 to 6% of all head and neck neoplasias, with an incidence ranging from 0.4 to 13.5 cases/100,000 individuals. Due to their clinicopathologic variability, the diagnosis of these tumors becomes a real challenge even for experient pathologists, which avoid the identification of biomarkers with effective clinical relevance. Therefore, the study of cellular proliferative and angiogenic markers, as well as the cellular DNA content definition could significantly improve the diagnosis of these neoplasias and favor a better understanding of their clinical behavior and prognostic determination. In the present study, using tissue microarray and immunohistochemistry techniques, and with the help of softwares and algorithms for digital analyses, the authors aim to characterize the proliferative pattern of 367 cases of salivary gland tumors with Ki67, Mcm-2 and HOXB7 biomarkers, as well as to evaluate the expression pattern of the angiogenic-related receptors neuropilin-1 and neuropilin-2, and the DNA content by image cytometry, correlating the results obtained with clinical variables, and, therefore, identifying the role played by these factors in the benign and malignant salivary gland tumors behavior, emphasizing their importance for the diagnosis and prognostic determination of patients affected by these neoplasias.

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FONSECA, FELIPE PAIVA; SENA FILHO, MARCONDES; ALTEMANI, ALBINA; SPEIGHT, PAUL M.; VARGAS, PABLO AGUSTIN. Molecular signature of salivary gland tumors: potential use as diagnostic and prognostic marker. JOURNAL OF ORAL PATHOLOGY & MEDICINE, v. 45, n. 2, p. 101-110, FEB 2016. (12/07519-9, 13/15955-6, 12/10781-7)

FONSECA, FELIPE PAIVA; BINGLE, LYNNE; SANTOS-SILVA, ALAN ROGER; LOPES, MARCIO AJUDARTE; COLETTA, RICARDO D.; BENEVENUTO DE ANDRADE, BRUNO AUGUSTO; MARIANO, FERNANDA VIVIANE; KOWALSKI, LUIZ PAULO; CARRINHO AYROZA RANGEL, ANA LUCIA; MARTINS, MANOELA DOMINGUES; et al. Immunoexpression of hoxb7 and hoxb9 in salivary gland tumours. JOURNAL OF ORAL PATHOLOGY & MEDICINE, v. 45, n. 9, p. 672-681, OCT 2016. (12/10781-7, 12/07519-9, 09/53839-2)

FONSECA, FELIPE PAIVA; BRIERLEY, DANIEL; WRIGHT, JOHN M.; SANTOS-SILVA, ALAN ROGER; ALMEIDA, OSLEI PAES; ROCHA, ANDRE CAROLI; VAN HEERDEN, WILLIE F.; HUNTER, KEITH D.. Polymorphous low-grade adenocarcinoma of the upper lip: 11 cases of an uncommon diagnosis. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, v. 119, n. 5, p. 566-571, MAY 2015. (12/07519-9)

FONSECA, FELIPE PAIVA; BENEVENUTO DE ANDRADE, BRUNO AUGUSTO; CARRINHO AYROSA RANGEL, ANA LUCIA; DELLA COLETTA, RICARDO; LOPES, MARCIO AJUDARTE; DE ALMEIDA, OSLEI PAES; VARGAS, PABLO AGUSTIN. Tissue microarray is a reliable method for immunohistochemical analysis of pleomorphic adenoma. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, v. 117, n. 1, p. 81-88, JAN 2014. (12/07519-9, 09/53839-2, 12/10781-7)

FONSECA, FELIPE PAIVA; MONTANHANA BASSO, MARCOS PAULO; MARIANO, FERNANDA VIVIANE; KOWALSKI, LUIZ PAULO; LOPES, MARCIO AJUDARTE; MARTINS, MANOELA DOMINGUES; CARRINHO AYROZA RANGEL, ANA LUCIA; SANTOS-SILVA, ALAN ROGER; VARGAS, PABLO AGUSTIN. Vascular endothelial growth factor immunoexpression is increased in malignant salivary gland tumors. ANNALS OF DIAGNOSTIC PATHOLOGY, v. 19, n. 3, p. 169-174, JUN 2015. (12/07519-9, 12/17659-2, 09/53839-2, 12/10781-7)

FONSECA, FELIPE P.; BINGLE, LYNNE; SANTOS-SILVA, ALAN R.; LOPES, MARCIO A.; DE ALMEIDA, OSLEI P.; DE ANDRADE, BRUNO A. B.; MARIANO, FERNANDA V.; KOWALSKI, LUIZ P.; RANGEL, ANA L. C. A.; MARTINS, MANOELA D.; et al. Semaphorins and neuropilins expression in salivary gland tumors. JOURNAL OF ORAL PATHOLOGY & MEDICINE, v. 45, n. 2, p. 119-126, FEB 2016. (12/07519-9, 09/53839-2, 12/10781-7)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FONSECA, Felipe Paiva. Semaforinas e neuropilinas em tumores de glândulas salivares. 2015. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba Piracicaba, SP.