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Expression of teneurins and teneurins C-terminal associated peptides (TCAPs) in the central nervous system of non-human primates (Cebus apella)

Grant number: 12/08833-9
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2012
Effective date (End): June 30, 2016
Field of knowledge:Biological Sciences - Morphology - Anatomy
Principal researcher:Cláudio Aparecido Casatti
Grantee:Kelly Regina Torres da Silva
Home Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

Teneurins (TENs) represent transmembrane type II proteins highly conserved among the species and mainly expressed in the central nervous system (CNS). This family is constituted by four homologues named as teneurins 1-4 in vertebrates. These proteins exert an important role in the neuronal interaction, besides a possible regulatory activity in gene transcription. Those proteins are important in neuronal interaction and possibly in genic transcription. Furthermore, the gene of TEN 1 and TEN 2 are located on chromosomes involved in mental abnormalities which enhances the contribution of this family of proteins in development and maintenance of the CNS. Previous studies determined that the terminal exon of each teneurin has a genomic sequence able to translate a peptide exhibiting high homology to corticotrophin-releasing factor (CRF). These peptides were named as c-terminal associated peptides (TCAPs 1-4), exerting significant modulatory activity in behavior disorders linked to stress. Studies focusing TENs and TCAPs have been of large interest, in view of the possible therapeutic applications of these peptides. However, basic information on these new peptidergic systems, such as their neuroanatomical distribution in the primate brain needs to be elucidated, in order to support their physiological findings and pharmacological use. In our previous study we analyzed de distribution of TEN 1 and TCAP-1 in monkey brain that demonstrated that the distribution of this peptidergic system is preserved in the non-human primate brain in areas directly or indirectly involved in stress and anxiety modulation. The results of immunoreactivity to TEN 1 showed difference with TCAP-1 in labeling pattern but not in neuroanatomical distribution. Consequently, the present study aims to evaluate the detailed distribution of others members of TENs and TCAPs in the non-human primate brain (Cebus apella) using immunohistochemistry and in situ hybridization methods to TEN 2, 3 e 4 e TCAP-2, 3 e 4. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TESSARIN, GESTTER W. L.; MICHALEC, OLA M.; TORRES-DA-SILVA, KELLY R.; DA SILVA, V, ANDRE; CRUZ-RIZZOLO, ROELF J.; GONCALVES, ALAIDE; GASPARINI, DANIELE C.; HORTA-JUNIOR, JOSE A. C.; ERVOLINO, EDILSON; BITTENCOURT, JACKSON C.; LOVEJOY, DAVID A.; CASATTI, CLAUDIO A. A Putative Role of Teneurin-2 and Its Related Proteins in Astrocytes. FRONTIERS IN NEUROSCIENCE, v. 13, JUN 27 2019. Web of Science Citations: 0.
TORRES-DA-SILVALI, K. R.; TESSARIN, G. W. L.; DIAS, C. A.; GUIATI, I. Z.; ERVOLINO, E.; GONCALVES, A.; BENETI, I. M.; LOVEJOY, D. A.; CASATTI, C. A. Teneurin-2 presence in rat and human odontoblasts. PLoS One, v. 12, n. 9 SEP 19 2017. Web of Science Citations: 3.
BATTAGELLO, DANIELLA S.; DINIZ, GIOVANNE B.; CANDIDO, PAULO L.; DA SILVA, JOELCIMAR M.; DE OLIVEIRA, AMANDA R.; DA SILVA, KELLY R. TORRES; LOTFI, CLAUDIMARA F. P.; DE OLIVEIRA, JOSE A.; SITA, LUCIANE V.; CASATTI, CLAUDIO A.; LOVEJOY, DAVID A.; BITTENCOURT, JACKSON C. Anatomical Organization of Urocortin 3-Synthesizing Neurons and Immunoreactive Terminals in the Central Nervous System of Non-Human Primates [Sapajus spp.]. FRONTIERS IN NEUROANATOMY, v. 11, JUL 24 2017. Web of Science Citations: 2.
TORRES-DA-SILVA, K. R.; DA SILVA, A. V.; BARIONI, N. O.; TESSARIN, G. W. L.; DE OLIVEIRA, J. A.; ERVOLINO, E.; HORTA-JUNIOR, J. A. C.; CASATTI, C. A. Neurochemistry study of spinal cord in non-human primate (Sapajus spp.). EUROPEAN JOURNAL OF HISTOCHEMISTRY, v. 60, n. 3, p. 175-182, 2016. Web of Science Citations: 5.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SILVA, Kelly Regina Torres da. Distribution of teneurin-related proteins in the central nervous system of non-human primates (Sapajus spp) and rats (Rattus norvegicus). 2016. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Instituto de Biociências. Botucatu Botucatu.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.