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Effects of the association of the composite Biosilicato ® / PLGA and laser therapy in the process of bone healing.

Grant number: 12/13117-0
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2012
Effective date (End): January 31, 2017
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal researcher:Ana Claudia Muniz Renno
Grantee:Kelly Rossetti Fernandes
Home Institution: Pró-Reitoria de Pós-Graduação e Pesquisa. Universidade Federal de São Paulo (UNIFESP). São Paulo , SP, Brazil

Abstract

Fractures of difficult consolidation and non-union are commonly founded in medical practice and are associated with high morbidity and mortality. Thus, it is necessary to search for new technologies that operate in the bone repair process and permit the osteoinduction and osteoconduction. Some features and biomaterials have been investigated in order to accelerate fracture healing and also be used as effective substitutes of bone tissue. Among them we mention the use of bioactive polymers, laser and others. In this context, this study aims to develop a composite Biosilicato ® / PLGA as a promising alternative to accelerate bone healing. Along with this composite is associated or not to check if the laser it can be considered an adjunct in the consolidation process. This study will evaluate the biocompatibility of composite Biosilicato ® / PLGA with or without the laser, through the evaluation of the biological responses induced by the material through in vitro studies. Furthermore, evaluate in vivo the effects of the composite Biosilicato ® / PLGA with or without Laser in the bone repair of the defects induced in the rat tibia. For this, will perform the cytotoxicity tests and genotoxicity of the composite (in vitro). For in vivo tests will be used 96 Wistar rats underwent the surgical procedure to perform the bone defect in the tibia and randomly distributed in to 4 groups: control, Biosilicato ®, Biosilicato ® / PLGA and Biosilicato ® / PLGA associated with the laser (830 nm , 30 mW, 1.07 W/cm2, 30 J/cm2). Still, each group will be divided into three subgroups, where the animals will be sacrificed on the 15th, 45th and 60th days. Will be conducted the following analysis: histopathology, morphometry, immunohistochemistry and biomechanics. It is hoped that this project, the development of new technologies with the use of biomaterials national, developing new approaches for the treatment of bone fractures.

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