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Relationship between MMP-9 and RECK expression in abnormal cervical smears and clinical evolution of squamous intraepithelial lesion

Grant number: 12/09746-2
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): October 01, 2012
Effective date (End): September 30, 2015
Field of knowledge:Biological Sciences - Morphology - Cytology and Cell Biology
Principal Investigator:Silvya Stuchi Maria-Engler
Grantee:Michelle Garcia Discacciati de Carvalho
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:08/03232-1 - HPV and tumor microenvironment, AP.TEM


This study aims to evaluate the expression of MMP-9 and RECK proteins in cervical smears of women undergoing routine Pap test, comparing the expression of these markers with cytological abnormalities and infectious agents, and to compare these markers with the types of Human Papillomavirus (HPV) and E6 and E7 oncoproteins expression. In women with atypical squamous cells of undetermined significance (ASC- US) and squamous intraepithelial lesions of low grade (LSIL), the objective is to compare the expression of MMP-9 and RECK with the lesion evolution. Women undergoing the Pap test will be included in this study and those with Pap test showing ASC-US or LSIL will be monitored over 18 months, with cytological, colposcopic and histological examination every six months. During the speculum examination will be collected cervical samples for microbiological and molecular tests. The odds ratio with 95% confidence interval will be calculated to measure the association between variables. The rates of progression and regression of cytological lesions over 18 months will be assessed by Kaplan-Meier method and compared by log-rank test, assuming a significance level of 5%.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MATHEUS, ERIKA R.; ZONTA, MARCO A.; DISCACCIATI, MICHELLE G.; PARUCI, PRISCILA; VELAME, FERNANDA; CARDEAL, LAURA B. S.; BARROS, SILVIA B. M.; PIGNATARI, ANTONIO C.; MARIA-ENGLER, SILVYA S.. MMP-9 Expression Increases According to the Grade of Squamous Intraepithelial Lesion in Cervical Smears. DIAGNOSTIC CYTOPATHOLOGY, v. 42, n. 10, p. 827-833, . (08/58817-4, 12/09746-2)
DISCACCIATI, MICHELLE G.; GIMENES, FABRCIA; PENNACCHI, PAULA C.; FAIAO-FLORES, FERNANDA; ZEFERINO, LUIZ C.; DERCHAIN, SOPHIE M.; TEIXEIRA, JULIO C.; COSTA, MARIA C.; ZONTA, MARCO; TERMINI, LARA; et al. MMP-9/RECK Imbalance: A Mechanism Associated with High-Grade Cervical Lesions and Genital Infection by Human Papillomavirus and Chlamydia trachomatis. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, v. 24, n. 10, p. 1539-1547, . (08/03232-1, 12/09746-2)
VENANCIO, PALOMA ALMEIDA; LOPES CONSOLARO, MARCIA EDILAINE; DERCHAIN, SOPHIE FRANCOISE; BOCCARDO, ENRIQUE; VILLA, LUISA LINA; MARIA-ENGLER, SILVYA STUCHI; CAMPA, ANA; DISCACCIATI, MICHELLE GARCIA. Indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase expression in HPV infection, SILs, and cervical cancer. CANCER CYTOPATHOLOGY, v. 127, n. 9, . (12/09746-2, 17/04926-6)

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