Effect of proteinase inhibitor BbCI, on membrane-bound neutrophil elastase

• Grant number: 11/21070-1
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: February 01, 2012
• End date: July 31, 2012
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Iolanda de Fátima Lopes Calvo Tibério
• Grantee: Rafael de Almeida dos Reis
• Supervisor: Caroline A. Owen
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Institution abroad: Harvard University, Boston, United States
• Associated to the scholarship: 09/15910-7 - Effect of proteinase inhibitor BbCI on elastase-induced lung injury in C57BL6 mice, BP.DR

Abstract

The main theory to elucidate the parenchyma destruction of emphysema, is the imbalance between proteinases and antiproteinases. The effect of proteinase inhibitor, extracted from Brazilian plants, on elastase-induced emphysema still unknown. The aim of this project is evaluate if BbCI is able to inhibit the membrane-bound proteinases on leukocyte surface. This project complement the evaluation of the BbCI treatment on experimental emphysema, and may be relevant for new therapeutical approaches on COPD treatment. (AU)