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Toll like receptor activation in the hypothalamus of mice and the modulation of energy balance: the role of AMPK/ACC and mTOR

Grant number: 12/07388-1
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): July 01, 2012
Effective date (End): January 31, 2013
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Marcio Alberto Torsoni
Grantee:Daniele Cristina Vitorino
Supervisor abroad: Serge Rivest
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Local de pesquisa : Université Laval, Canada  
Associated to the scholarship:09/16775-6 - Toll like receptor activation in the hypothalamus rats and the modulation of energy balance: the role of AMPK/ACC and mTOR, BP.DR

Abstract

The inflammatory process which contributes to the obesity setting has now widely being studied. The high consumption of saturated fat and pathogenic agents can lead to an increase in inflammatory cytokines through toll like receptor (TLR), interfering with the signaling pathway proteins as AMPK, ACC and mTOR, which are known to control the hypothalamic energy balance. The modulation of these proteins following the TLR activation in the hypothalamus can be an important event triggering chronic inflammatory process; besides, the members of TLR family might be important therapeutic targets, contributing to the better understanding of complexes events regarding to the obesity. Therefore, through the use of knockout mice to the proteins involved in the TLR4 signaling pathway (Myd88 and TRIF) and in situ hybridization, the aim of this study is to evaluate the AMPK modulation in the hypothalamus in animals LPS treated. (AU)