Oxidative stress evaluation in patients with acromegaly

• Grant number: 12/15010-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2012
• End date: August 31, 2014
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Vania dos Santos Nunes Nogueira
• Grantee: Ana Clara Muraro Bonini
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Acromegaly is a chronic disease due excessive production of growth hormone (GH) and the majority of the patients it is caused by a pituitary macroadenoma. Many studies have shown an increase of mortality in these patients compared with the general population, particularly as a result of cardiovascular complications. Researches involving transgenic rats expressing bovine GH and developing acromegaly complications, like hypertension and diabetes mellitus and hypercholesterolemia, have evidenced deterioration in endothelial function. The present study aims to evaluate the serum oxidative stress in a group of patients with acromegaly, comparing the results with a group of healthy individuals and correlated with serum levels of GH and IGF1. Approximately 28 patients with Acromegaly at the Clinics Hospital - Univ Estadual Paulista will be enrolled in this study and 28 healthy individuals .Will be excluded individuals with liver and kidney dysfunctions, smoking, alcohol intake over 60 grams per day and users of antioxidant supplements. The oxidative stress will be assessment by the measure of antioxidant capacity; the analysis of lipid peroxidation; the comet assay and dosage of lipophilic antioxidants. The results will be compared between both groups and among acromegaly group the results will be correlated with GH and IGF1 levels.(AU)