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Acromegaly: mineral density, microarquitecture and bone strength before and after treatment with biphosphonate NEW TITLE: Bone microarchitecture and strength evaluation in adults with diagnosis of acromegaly

Grant number: 16/23765-0
Support Opportunities:Regular Research Grants
Duration: August 01, 2018 - July 31, 2022
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Raquel Soares Jallad
Grantee:Raquel Soares Jallad
Host Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Associated researchers: Felipe Henning Gaia Duarte ; Marcello Delano Bronstein ; Paula Paes Batista da Silva ; Regina Matsunaga Martin ; Rosa Maria Rodrigues Pereira


Several population studies identified risk factors of fractures such as age, history of fracture, gonadal function and bone mineral density. Recently, the literature has indicated that bone microarchitecture should also be considered as an independent risk factor for fracture and bone strength.Patients with acromegaly represents a population with a high potential for vertebral fractures and reduced bone mineral density (BMD) in some places, especially when associated with multiple pituitary hormone deficiency.Studies evaluating bone microarchitecture in acromegaly are scarce. Thus, this study provides the opportunity to assess bone microarchitecture and strengh biochemical in acromegaly as well as the impact of treating the disease and / or osteoporosis in this parameter. Eventually, these data can allow the early diagnosis of the risk of fracture, as well as better therapeutic strategy to minimize the occurrence of fractures (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA, PAULA P. B.; PEREIRA, ROSA M. R.; TAKAYAMA, LILIAM; BORBA, CLARISSA G.; DUARTE, FELIPE H.; TRARBACH, ERICKA B.; MARTIN, REGINA MATSUNAGA; BRONSTEIN, MARCELLO D.; TRITOS, NICHOLAS A.; JALLAD, RAQUEL S.. Impaired Bone Microarchitecture in Premenopausal Women With Acromegaly: The Possible Role of Wnt Signaling. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, v. 106, n. 9, p. 2690-2706, . (16/23765-0)

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