Characterization of the inter-relation between the Notch signaling pathway and TLR in experimental paracoccidioidomycosis

• Grant number: 12/14955-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): November 01, 2012
• Effective date (End): August 31, 2016
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Sandro Rogerio de Almeida
• Grantee: Lavínia Maria Dalmas Romera
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Paracoccidioidomycosis (PCM) is a systemic disease caused by Paracoccidioides brasiliensis, a fungus that exhibits thermal dimorphism. The P. brasiliensis interacts with antigen presenting cells (APCs), changing its main biological functions. Among the APCs, macrophages are cells that play an important role in the induction and regulation of the immune response and / or inflammatory response. Are cells of the mononuclear phagocytic system capable of recognizing the pathogen-associated molecular pattern (PAMPs - pathogen-associated molecular pattern) by expression of pattern recognition receptors (PRR - Pattern Recognition Receptors). It is known that the Notch signaling interferes with the activity of macrophages during the inflammatory response by modulating the pattern of cytokines, and often, this occurs in conjunction with the TLR activation through stimulation with LPS. Several studies have demonstrated the existence of cooperation between Notch and TLR, modulating the activation of target genes of Notch, which in turn negatively regulates a subset of genes TLR. Thus, the main objective of this study is to evaluate the correlation between these two signaling pathways in experimental PCM. Certainly, the understanding of these issues will be important for better understanding of innate and adaptive immune response in experimental PCM.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DAL'MAS ROMERA, LAVINIA MARIA; KAIHAMI, GILBERTO HIDEO; JANNUZZI, GRASIELLE PEREIRA; FOGACA DE ALMEIDA, JOSE ROBERTO; DE ALMEIDA, SANDRO ROGERIO. The Critical Role of Notch1-TLR 4 Signaling in the Inflammatory and Fungicidal Activity of Macrophages Against Paracoccidioides brasiliensis Strain Pb18. Mycopathologia, v. 182, n. 9-10, p. 797-807, OCT 2017. (12/14955-0)