Leishmaniasis is a disease caused by protozoan trypanosomatids of the genus Leishmania, which infect preferentially macrophages. The disease can present itself in cutaneous, mucocutaneous or visceral forms, and 350 million people worldwide are at risk of infection. Several factors influence the shape and severity of the disease, among which the species of Leishmania and the host immune response are the most important. Studies based on animal models susceptible and resistant to Leishmania show how the immune system of hosts with different profiles affects the survival of the parasite. Considering the importance of macrophages in the course of Leishmania infection, the potential role of CD100 (that we showed to be expressed by macrophages from BALB/c and C57BL/6 mice) in the modulation of macrophage activation, and our data that sCD100 increases the infectivity of this cell by the parasite, we aim to clarify how CD100 participates in macrophage infection by Leishmania. For this, we will analyze the expression and localization of the protein in macrophages infected or not by Leishmania and the role of the soluble molecule and the one expressed by the macrophage in the infection.
News published in Agência FAPESP Newsletter about the scholarship: