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Biomolecular and histologic study of remodeling, fixation and integration of bone grafts "onlay" with the use of N-Butyl-2-cyanoacrylate, titanium screw or lag-screw technique.

Grant number: 12/15526-5
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): December 01, 2012
Effective date (End): November 30, 2013
Field of knowledge:Health Sciences - Dentistry - Oral and Maxillofacial Surgery
Principal researcher:Luiz Antonio Salata
Grantee:Alex Martins Machado
Home Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


The bone graft "onlay" has become a routine procedure when the increase in bone volume is required for rehabilitation with dental implants. The use of screws Titanium (Ti) is the method of fixing bone grafts "onlay" most used today, however have some drawbacks. These problems have stimulated interest in alternative techniques of graft fixation. Recent experimental studies in animal models have analyzed the bone response and stability at sites of fractures fixed with cyanoacrylate-based adhesive, being very efficient, however, there are no studies that evaluated the remodeling of grafts "onlay" in presence of this material and not fixing these grafts promoted by the adhesive and its homologs. There are different forms of this compound and members of his family include: Methyl-cyanoacrylate, Ethyl-cyanoacrylate, Octyl-cyanoacrylate, N-Butyl-2-cyanoacrylate (NB-Cn), among others. The NB-Cn was approved for clinical use in 1996 and is becoming a popular method for closing cutaneous wounds, and an adhesive polymer belonging to the new generation of cyanoacrylates, which are composed of long chain, and therefore are more biocompatible than those used initially. Thus, this study aims to analyze the use of the compound NB-Cn in onlay bone grafts against the use of titanium screws, looking for it, through molecular biology and histology remodeling, fixing and integrating them.

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