Influence of diabetes on pharmacokinetics of lopinavir in HIV-infected women during pregnancy and at delivery

• Grant number: 12/17113-0
• Support type: Scholarships in Brazil - Master
• Effective date (Start): October 01, 2012
• Effective date (End): July 31, 2014
• Field of knowledge: Biological Sciences - Pharmacology - Clinical Pharmacology
• Principal researcher: Vera Lúcia Lanchote
• Grantee: Roberta Natália Cestari
• Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Lopinavir (LPV) is currently one of the most commonly used protease inhibitors in pregnant women with HIV. The aim of the study is to evaluate the influence of diabetes mellitus (DM) on the pharmacokinetics of lopinavir in HIV-infected women during the third trimester of pregnancy, at delivery and in umbilical cord. Nondiabetic HIV-infected women during the third trimester of pregnancy (control group, n = 8) and diabetic HIV-infected women during the third trimester of pregnancy (n = 8), treated with 133.3 mg lopinavir and 33.3 mg ritonavir (1 capsule of Kaletra®, Abbott) every 12 h, will be investigated. Serial maternal blood samples will be collected at steady state during the dose interval of 12 h. At delivery, will also be collected simultaneously blood samples from maternal women and umbilical cord, as well as a sample of amniotic fluid. Plasma concentrations of total and free lopinavir will be analysed by LC-MS/MS. Pharmacokinetic parameters will be evaluated using the WinNonlin software. The influence of diabetes on the pharmacokinetics of lopinavir in HIV-infected women during pregancy will be evaluated using the Mann-Whitney two-tailed unpaired test, pd 0.05.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CESTARI, Roberta Natália. Kinetic disposition and placental transfer of lopinavir and ritonavir in pregnant women with HIV. 2014. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto Ribeirão Preto.