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Study of the mechanisms involved in Hsc82p-regulation of the activity of proteasome in yeast

Grant number: 12/17654-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2012
Effective date (End): October 31, 2014
Field of knowledge:Biological Sciences - Biochemistry
Principal Investigator:Fernanda Marques da Cunha
Grantee:Diana Granado Pinheiro
Home Institution: Escola de Artes, Ciências e Humanidades (EACH). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Among the various systems responsible for the maintenance of eukaryotic cell physiology is the ubiquitin-proteasome system (UPS). UPS function is especially relevant in the aging context, since its dysfunction is part of the pathogenesis of Alzheimer's and Parkinson's diseases. This project's main objective is to better understand UPS regulation during the aging of Saccharomyces cerevisiae by using calorie restriction as a mean to modulate the aging rate. A comprehensive characterization of UPS function as well as evidences about its regulation in aging will contribute toward the development of strategies or identification of targets for intervention in pathological processes, especially those associated with aging.