Effects of bone remodelling on calcium mass transfer during hemodialysis: study of patients with hyperparathyroidism pre and post parathyroidectomy

• Grant number: 12/19697-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): November 01, 2012
• Effective date (End): April 30, 2014
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Rosa Maria Affonso Moysés
• Grantee: Gisele Lins Antunes
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Chronic renal failure is associated to a deterioration of mineral homeostasis due to bone abnormalities related to a positive calcium and phosphorus mass balance resulting in higher risk of fractures, calcification of arteries and ultimatelly leading to a worse cardiac prognosis. In clinical practice the amount of calcium in dialisate doensn't seem to be a concern and an additional therapeutic tool to help manage the mineral abnormalities. Our own group recently suggested that bone remodeling could affect calcium mass transfer during hemodialysis. However, bone remodeling was then presumed by PTH and osteocalcin. The aim of this study is to analyse the influence of bone remodeling on calcium mass transfer during hemodialysis in patients with hyperparathyroidism pre and post parathyroidectomy. A total of fifteen patients will be selected and all of them will have a bone biopsy done, quantitative osteocalcin in tissue and serum remodeling bone markers. They will go through hemodialysis sessions with dialisate calcium of 1.25; 1.5;1.75 mmol/L pre and post parathyroidectomy being their own controls.(AU)