Proteomic analysis of the effects of Aloe barbadensis in the kidney of streptozotocin-induced diabetic rats

• Grant number: 12/22278-8
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: December 01, 2012
• End date: September 30, 2015
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Dulce Elena Casarini
• Grantee: Lilian dos Santos
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated research grant: 10/51904-9 - Renin angiotensin and kallikrein kinin systems in hypertension, obesity, diabetes, desnutrition and sepsis: molecular, cellular and physiopathologic mechanisms, AP.TEM

Abstract

Diabetic nephropathy (DN) is a common microvascular complication in diabetes mellitus (DM). Although insulin and oral antidiabetic presents effectives effects in the treatment of diabetes, they have side effects and high cost. The Aloe vera belongs to the family Asphodelaceae and has more than 75 active components that act either alone or synergistically, promoting anti-inflammatory, antibacterial, antioxidant, hypoglycemic, among others. Proteomics is the science that studies a proteome (set of proteins expressed by an organism in a given situation) enabling quantitative and qualitative evaluations of proteins that act in cellular metabolism. Although several studies involving experimental models show that Aloe vera has hypoglycemic effects comparable to drugs currently used to treat diabetes, the mechanisms of action have not been fully established and there is no correlation between each individual component and the therapeutic effects. Therefore, more studies are needed to elucidate the hypoglycemic properties of Aloe barbadensis. (AU)