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Acute and chronic responses of the mucociliary transport and autonomic function of patients with chronic obstructive pulmonary disease submitted to aerobic training

Grant number: 12/11174-7
Support type:Scholarships in Brazil - Master
Effective date (Start): January 01, 2013
Effective date (End): February 28, 2014
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal researcher:Dionei Ramos
Grantee:Marceli Rocha Leite
Home Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil


The mucociliary transport, a vital lung defense mechanism, is deficient in patients with COPD. It is known that physical exercise and autonomic stimulation influence mucociliary clearance, however the relation between aerobic training and autonomic nervous system the improvement of lung defense mechanism is still unclear. Objective: To evaluate the response of acute and chronic mucociliary transport and behavior of the autonomic nervous system of patients with COPD undergoing an aerobic training as well as investigate possible association between these variables. Methods: Individuals diagnosed with COPD in both sexes, aged over 45 years be subject to a 12 weeks of aerobic training and assessed by mucociliary transport through test of saccharine transit time (TST) and the autonomic nervous system activity through heart rate variability (HRV). For comparison, will be evaluated about the same variables a control group, with individuals diagnosed with COPD. Statistical analysis: Will use the statistical program Graphpad Prism ®. The normality of the data will be assessed by the Shapiro-Wilk test. For intergroup analysis will be used unpaired t test or Mann-Whitney test. The study of TTS and HRV variables will be analyzed by the technique of analysis of variance for repeated measures model in independent group, with the additional test for multiple comparisons of Bonferroni or Dunn, as the adherence of the data to Gaussian distribution. Correlations will be evaluated using the Pearson or Spearman coefficients. The significance level used will be p<0.05. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LEITE, MARCELI ROCHA; CIPULO RAMOSA, ERCY MARA; COELHO FIGUEIRA FREIRE, ANA PAULA; DE ALENCAR SILVA, BRUNA SPOLADOR; NICOLINO, JULIANA; MARQUES VANDERLEI, LUIZ CARLOS; RAMOS, DIONEI. Analysis of Autonomic Modulation in Response to a Session of Aerobic Exercise at Different Intensities in Patients With Moderate and Severe COPD. COPD-Journal of Chronic Obstructive Pulmonary Disease, v. 15, n. 3, p. 245-253, . (12/11174-7)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
LEITE, Marceli Rocha. Resposta da função autonômica, transporte mucociliar e potência aeróbia máxima de pacientes com doença pulmonar obstrutiva crônica submetidos a um treinamento aeróbio. 2014. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Ciências e Tecnologia. Presidente Prudente Presidente Prudente.

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