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Acute and chronic responses of the mucociliary transport and function autonomic in patients with COPD submitted to a strenght training.

Grant number: 11/15303-3
Support type:Scholarships in Brazil - Master
Effective date (Start): May 01, 2012
Effective date (End): February 28, 2014
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal researcher:Ercy Mara Cipulo Ramos
Grantee:Juliana Nicolino
Home Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil


Introduction: Mucociliary dysfunction is one of the clinical manifestations present in patients with chronic obstructive pulmonary disease (COPD). In addition, there are systemic manifestations such as skeletal muscle dysfunction that is associated with fatigue, dyspnea and exercise intolerance. Therefore, strength training becomes an important component in the process of pulmonary rehabilitation (PR). In addition, exercises are associated with an increased level of adrenergic mediators and it is expected that the mucociliary transport change during or after physical activity, since it is known that autonomic stimulation influences mucociliary clearance. Objectives: To evaluate and compare the acute and chronic response of the mucociliary transport of patients with COPD compared to a strength training protocol, and investigate the involvement of the autonomic nervous system (ANS) in such a response. Methods: Patients with COPD and healthy subjects will be assessed by mucociliary transport from saccharin transit time (STT) and the autonomic nervous system activity by heart rate variability (HRV) before and after a strength exercise and before and after protocol strength training 12 weeks. Statistical analysis: The study of HRV and TTS variables will be determined by means of analysis of variancefor repeated measures model in independent groups, complemented by the Bonferroni or Dunn multiple comparisons . Correlations will be evaluated using the Pearson or Sperman coefficients. The choice of tests will depend on the normal distribution of data. The level of significance will be p<0,05.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
NICOLINO, Juliana. Resposta do transporte mucociliar, função autonômica e força muscular de pacientes com doença pulmonar obstrutiva crônica submetidos a um treinamento resistido. 2014. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Ciências e Tecnologia. Presidente Prudente Presidente Prudente.

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